中心簡介 / 同仁通訊錄

生命科學小組


姓名: 李明道( Ming-Tao Lee )
分機: 7109
電子郵件: mtlee@nsrrc.org.tw
學歷:
  • 國立中央大學 物理 博士 (2004)
  • 國立中央大學 物理 學士 (1992)
經歷:
  • 國家同步輻射研究中心副研究員 (2014迄今)
  • 國立中央大學物理系合聘副教授 (2014迄今)
  • 國家同步輻射研究中心助研究員 (2005迄今)
  • 國立中央大學物理系合聘助理教授 (2009迄今)
  • 國立中央大學物理系博士後研究 (2004-2005)
負責實驗站: TLS BL13A X光散射與繞射實驗站
研究領域:
  • 生物膜結構
  • 蛋白質-生物膜交互作用
  • 蛋白質-蛋白質交互作用
  • 藥物分子-生物膜作用
  • 生物材料
代表作:
  • Ming-Tao Lee*, Biophysical characterization of peptide–membrane interactions. Advances in Physics: X 3, 1408428 (2018).
  • Ming-Tao Lee, Wei-Chin Hung, Meng-Hsuan Hsieh, Hsiung Chen, Yu-Yung Chang, Huey W. Huang*, Molecular State of the Membrane-Active Antibiotic Daptomycin. Biophys. J. 113, 82-90 (2017).
  • Meng-Hsuan Hsieh, Yu-Shuan Shiau, Horng-Huei Liou, U-Ser Jeng, Ming-Tao Lee*, and Kuo-Long Lou*, Measurement of Hanatoxin-induced Membrane Thinning with Lamellar X-ray Diffraction (LXD). Langmuir 33, 2885-2889 (2017).
  • Wei-Chin Hung, Ming-Tao Lee, Hsien Chung, Yi-Ting Sun, Hsiung Chen, Nicholas E. Charron, and Huey W. Huang*, Comparative Study of the Condensing Effects of Ergosterol and Cholesterol. Biophys. J. 110, 2026-2033 (2016).
  • Ming-Tao Lee*, Tzu-Lin Sun, Wei-Chin Hung*, and Huey W. Huang*, Process of Inducing Pores in Membranes by Melittin. PNAS 110, 14243-14248 (2013).
  • Chun-Jen Su, Shiuan-Shiaou Wu, U-Ser Jeng*, Ming-Tao Lee*, An-Chung Su, Kuei-Fen Liao, Wei-Yu Lin, Yu-Shan Huang, and Chun-Yu Chen, Peptide-induced bilayer thinning structure of unilamellar vesicles and the related binding behavior as revealed by X-ray scattering. BBA-Biomembranes 1828, 528-534 (2013).
  • Ming-Tao Lee, Wei-Chin Hung, Fang-Yu Chen and Huey W. Huang, Mechanism and kinetics of pore formation in membranes by water-soluble amphipathic peptides, PNAS 105, 5087-5092 (2008).
  • Wei-Chin Hung, Fang-Yu Chen, Chang-Chun Lee, Yen Sun, Ming-Tao Lee and Huey W. Huang, (2008) Membrane Thinning Effect of Curcumin, Biophys. J. 94, 4331-4338.
  • Ming-Tao Lee, Wei-Chin Hung, Fang-Yu Chen and Huey W. Huang (2008) Mechanism and kinetics of pore formation in membranes by water-soluble amphipathic peptides, PNAS 105, 5087-5092.
  • Wei-Chin Hung, Ming-Tao Lee, Fang-Yu Chen and Huey W. Huang, (2007) The Condensing Effect of Cholesterol in Lipid Bilayers, Biophys. J. 92, 3960-3967.
  • Ming-Tao Lee, Wei-Chin Hung, Fang-Yu Chen and Huey W. Huang (2005) Many-body effect of Antimicrobial peptides: on the correlation between lipid’s spontaneous curvature and pore formation, Biophys. J. 89, 4006-4016.
  • Huey W. Huang, Fang-Yu Chen and Ming-Tao Lee (2004) Molecular mechanism of peptide-induced pores in membranes, Phys. Rev. Lett. 92, 198304.
  • Ming-Tao Lee, Fang-Yu Chen and Huey W. Huang (2004) Energetics of pore formation induced by membrane active peptides, Biochemistry 43, 3590-3599.
  • Fang-Yu Chen, Ming-Tao Lee and Huey W. Huang (2003) Evidence for membrane thinning effect as the mechanism for peptide-induced pore formation, Biophys. J. 84, 3751-3758.
  • Fang-Yu Chen, Ming-Tao Lee and Huey W. Huang (2002) Sigmoidal concentration dependence of antimicrobial peptide activities: a case study on alamethicin, Biophys. J. 82, 908-914.