中心簡介 / 同仁通訊錄

生命科學小組


姓名： 李耀昌( Yao-Chang Lee )
分機： 7333
電子郵件： yclee@nsrrc.org.tw
學歷：
  • 國立清華大學 化學博士 (2002)
經歷：
  • 國家同步輻射研究中心 副研究員 (2018-)
  • 國家同步輻射研究中心 助研究員 (2004-2017)
  • 國立清華大學 化學系 兼任副教授 (2020/2-)
  • 國立中央大學 光電科學與工程系 兼任副教授 (2019/8-)
  • 財團法人工業技術研究院 量測技術發展中心 研究員(2002~2003)
負責實驗站：
  • 紅外光束線及紅外光譜顯微術實驗站發言人
研究領域：
  • 發展紅外光譜影像結合蠟吸附動力學法檢測醣蛋白醣體異化之疾病快速篩檢技術。
  • 開發紅外蠟吸附動力學法結合VB.NET建構人工智慧的疾病檢測演算法。
  • 開發以紅外蠟吸附動力學法進行組織移植評估之研究。
  • 以同步輻射紅外光譜顯微影像技術及共軛焦拉曼光譜顯微技術之古生物化石成分分析。
專利：
  • Y.-C. Lee (李耀昌), P. Y. Huang, C.-I. Chen, “Method for detecting cancer and reagents for use therein”, R.O.C. patent, No. 404931, (2013); Japan patent, 2009-119309, (2013); USA patent, US-8-354,222 B2, (2013). 2017年授權予民間第三方公司，2017~2019技轉
  • Y.-C. Lee (李耀昌), P. Y. Huang, “Method for Cancer Grading“, R.O.C. patent, No. 107145326 (2020); Japan patent, P6782818(2020); European Patent Application, EP3578982 (2020) (German 602018008644.7; UK 3578982; France 3578982); USA patent, US 10,948,482 B2, (2021) 
  1. 李耀昌，王浩偉，“即時紅外化學影像光譜裝置 (Real-time infrared chemical imaging spectrometer)”, 臺灣專利, 第203435 (2004).
  2. 李耀昌，柯俊宏，劉家嵩，“光學式金屬辨識裝置及方法 (Metal-recognized apparatus and methodology by optical reflection)”, 臺灣專利, 第I226,435 (2005).
  3. 李耀昌，林雁容，劉定坤，“多重反射螢光探頭 (Multi-reflection collection probe of Fluorescence inspection)”, 臺灣專利, 第I230,789 (2005).
  4. Y.-C. Lee and H.-W. Wang, “Real-Time infrared chemical imaging spectroscopic apparatus” , USA Patent, US 6992293 B2 (2006).
  5. 李耀昌，黃佩瑜 “一種新型顯微鏡照明裝置” 臺灣專利, 第09,840,927,640 (2009)
  6. Y.-C. Lee and P. Y. Huang, “A novel microscope illuminator”, Japan  Patent No. 3150912 (2009)
  7. Y.-C. Lee, P. Y. Huang and C.-I. Chen, Method for detecting cancer and reagents for use therein, USA patent, US-8-354222 B2 (2013)
  8. 李耀昌、黃佩瑜、陳慶曰, “癌化生物樣品之檢測方法及其使用之檢測試劑”, 日本專利, 特許第5266556號 (2013)
  9. 李耀昌、黃佩瑜、陳慶曰, “癌化生物樣品之檢測方法及其使用之檢測試劑”,臺灣專利, 第404931號 (2013). 已授權（非專屬）並技轉給第三方民間公司
  10. Y.-C. Lee (李耀昌), P. Y. Huang, “Method for Cancer Grading“, US 16/002,538(pending); EP18179385.2 (2018)(pending)
代表作：
  • Y.-H. Hsieh, J.-H. Zhang, W.-C. Chuang, K.-H. Yu, X.-B. Huang, Y.-C. Lee (李耀昌), and C.-I. Lee*, “An in Vitro Study on the Effect of Combined Treatment with Photodynamic and Chemical Therapies on Candida Albicans”, Int. J. Mol. Sci. 19, 337 (2018) (IF: 5.57) (citation: 44)
  • Priprem, Y.-C. Lee (李耀昌), W. Limphirat, S. Tiyaworanant, K. Saodaeng, J. Chotitumnavee, N. Kowtragoon, “Eucalyptus ash alters secondary protein conformation of human grey hair and facilitates anthocyanin dyeing” PLoS ONE, 13, 7, e0199696(2018) https://doi.org/10.1371/journal.pone.0199696 (IF: 3.7) (citation:3)
  • L. J. Bancin, B. A. Walther, Y.-C. Lee (李耀昌), A. Kunz, “Two-dimensional distribution and abundance of micro- and mesoplastic pollution in the surface sediment of Xialiao Beach, New Taipei City, Taiwan”, Mar. Pollut. Bull., 140, 75–85 (2019) (IF: 5.8) (citation: 59)
  • J. Rathod, J.-S. Jean, W.-T. Jiang, I-H. Huang, B. H. Liu, Y.-C. Lee (李耀昌), “Micro-colonization of arsenic-resistant Staphylococcus sp. As-3 on arsenopyrite (FeAsS) drives arsenic mobilization under anoxic sub-surface mimicking conditions”, Sci. Total Environ., 669, 527–539 (2019) (IF: 9.8) (citation: 20)
  • W.-J. Syu, C.-C. Huang, J.-K. Hsiao, Y.-C. Lee (李耀昌), Y.-T. Huang, P. Venkatesan, P.-S. Lai, “Co-precipitation Synthesis of Near-infrared Iron Oxide Nanocrystals on Magnetically Targeted Imaging and Photothermal Cancer Therapy via Photoablative Protein Denature”, Nanotheranostics, 3, 236 (2019) (IF: 4.8) (citation: 17)
  • Y.-T. Weng, J. Rathod, B. Liang*, C.-C. Wang, Y. Iizuka, N. Tamura, C.-L. Chen, Y.-C. Lee (李耀昌), “Black carbon enriches short-range-order ferrihydrite in Amazonian Dark Earth: Interplay mechanism and environmental implications”, Sci. Total Environ., 725,10, 138195 (2020) (IF: 9.8) (citation: 6)
  • I.-M. Lin, C.-M. Chou, M.-C. Li, R.-H. Guo, C.-K. Lee, H.-J. Li, Y.-W. Chiang, Y.-H. Lin, Y.-C. Lee (李耀昌), C.-J. Su, U.-S. Jeng, W.-T. Chuang*, “Superhelices with tunable twisting power directed from supramolecular pairing of focal asymmetry in achiral dendron‐jacketed block copolymers” J. Mater. Chem. C, 8, 1923-1932 (2020) (IF: 6.4) (citation: 8)
  • Y.-L. Cho, Y.-C. Lee (李耀昌), L.-C. Hsu, C.-C. Wang, P.-C. Chen, S.-L. Liu, H.-Y. Teah, Y.-T. Liua, Y.-M. Tzoua, “Molecular mechanisms for Pb removal by Cyanidiales: a potential biomaterial applied in thermo-acidic conditions”, Chem. Eng. J., 401, 125828 (2020) (IF: 16.744) (citation: 16)
  • P. P. Biswas, B. Liang*, G. Turner-Walker 2, J. Rathod, Y.-C. Lee (李耀昌), C.-C. Wang, C.-K. Chang, “Systematic Changes of Bone Hydroxyapatite along a Charring Temperature Gradient: An integrative Study with Dissolution Behaviour”, Sci. Total Environ., 766, 142601(2021) (IF: 9.8) (citation: 21)
  • R.-H. Guo, C.-M. Chou, C.-C. Wang, M.-J. Deng, J.-M. Lin, C.-Y. Chen, Y.-C. Lee (李耀昌), Y.-W. Chiang, W.-T. Chuang, “Biomimetic strategies for 4.0 V all-solid-state flexible supercapacitor: Moving toward eco-friendly, safe, aesthetic, and high-performance devices”, Chem. Eng. J., 414, 128842 (2021) (IF: 16.744) (citation: 9)
  • S,-W. Chang, R.-G. Chen, T.-H. Liu, Y.-C. Lee (李耀昌), C.-S. Chen, T.-S. Chiu and C.-Y. Ko, “Dietary Shifts and Risks of Artifact Ingestion for Argentine Shortfin Squid Illex argentinus in the Southwest Atlantic”, Front. Mar. Sci., 8:675560 (2021). DOI: 10.3389/fmars.2021.675560 (IF: 5.247) (citation: 1)
  • K. Lakshmanan, W.-H. Huang, S. A. Chala, B. W. Taklu, E. A. Moges, J.-F. Lee, P.-Y. Huang, Y.-C. Lee (李耀昌), M.-C. Tsai*, W.-N. Su*, and B. J. Hwang*, “Highly Active Oxygen Coordinated Configuration of Fe Single-atom Catalyst toward Electrochemical Reduction of CO2 into Multi-carbon Products”, Adv. Funct. Mater., 32, 2109310 (2022) (IF: 19.924) (citation: 34)
  • P. P. Biswas, G. Turner-Walker, J. Rathod, B. Liang*, C.-C. Wang, Y.-C. Lee (李耀昌), and H.-S. Sheu, “Sustainable Phosphorus Management in Soil Using Bone Apatite”, J. Environ. Manage 305, 114344 (2022) (IF: 8.7) (citation: 7)
  • E.-L. Cho, Y.-M. Tzou, C.-C. Wang, Y.-C Lee (李耀昌), L.-C. Hsu, S.-L. Liu, A. Assakinah, Y.-H. Chen, N. A. T. Than, Y.-T. Liu*, J. Rinklebe, “Removal and concurrent reduction of Cr(VI) by thermo-acidophilic Cyanidiales: a novel extreme biomaterial enlightened for acidic and neutral conditions”, J. Hazard. Mater., 130334, ISSN 0304-3894 (2022), DOI: https://doi.org/10.1016/j.jhazmat.2022.130334 ( IF: 13.6) (citation: 5)
  • P.-Y. Lin, P.-Y. Huang, Y.-C Lee* (李耀昌) and C.-S. Ng*, “Analysis and comparison of protein secondary structures in the rachis of avian flight feathers”, PeerJ, 10:e12919 (2022), DOI: http://doi.org/10.7717/peerj.12919 ( IF: 3.06) (citation: 4)
  • Y.-T.Chen, P.-Y.Huang, J.-Y.Wang, Y.-C. Lee* (李耀昌) and C.-Y. Chai*, “An innovative diagnosis in gastrointestinal neuroendocrine neoplasms using Wax-Physisorption-Kinetics-based FTIR Imaging.“ Sci. Rep., 12, 17168 (2022). DOI: https://doi.org/10.1038/s41598-022-22221-0 ( IF: 4.6)
  • Y.-L. Cho, Y.-M. Tzou, C.-C. Wang, Y.-C. Lee (李耀昌), L.-C. Hsu, S.-L. Liu, A. Assakinah, Y.-H. Chen, N. A. T. Than, Y.-T. Liu*, J. Rinklebe, "Removal and Concurrent Reduction of Cr(VI) by Thermoacidophilic Cyanidiales: a Novel Extreme Biomaterial Enlightened for Acidic and Neutral Conditions", J. Hazard. Mater. 445, 130334 (2023) ( IF: 13.6) (citation: 5)
  • C-T Chiu, J.-K. Cao, P.-W. Wang, Y.-N. Wu, Y.-C. Lee (李耀昌), Y.-R. Jeng*, D.-B. Shieh*, R. R. Reisz*, “Mammalian tooth enamel functional sophistication demonstrated by combined nanotribology and synchrotron radiation FTIR analyses”, iScience, 26, 105679 (2023) ( IF: 6.107 ) (citation: 1)
  • Y.-T. Chen, P.-Y. Huang, C.-Y. Chai, S. Yu, Y.-L. Hsieh, H.-C. Chang, C.-W. Kuo, Y.-C. Lee* (李耀昌), and H.-S. Yu*,“Early detection of the initial stages of LED light-triggered non-alcoholic fatty liver disease by wax physisorption kinetics-Fourier transform infrared imaging”,  Analyst, 148(3), 643-653 (2023)  (IF: 5.227)