About NSRRC / Staff Directory

Molecular Science Group


Name： 劉振霖( Chen-Lin Liu )
EXT.： 7207
E-mail： liu.cl@nsrrc.org.tw
Education：
  • National Tsing Hua University, Hsinchu, Taiwan/Taiwan International Graduate Program, Taipei, Taiwan (Ph. D. in Physical Chemistry) Sep. 2004~Feb. 2008
  • National Chiao Tong University, Hsinchu, Taiwan(M. S. in Chemistry) Sep. 1999 – Jun. 2001
  • National Chiao Tong University, Hsinchu, Taiwan(B. S. in Chemistry) Sep. 1995 – Jun. 1999
Experience：
  • National Synchrotron Radiation Research Center Associate Scientist (Jan. 2017~now)
  • International PhD Program for Science, NATIONAL SUN YAT-SEN UNIVERSITY, Associate Professer (Aug. 2024~now)
  • National Synchrotron Radiation Research Center Assistant Scientist (July 2010~Dec. 2016)
  • University of California, Berkeley & Lawrence Berkeley National Laboratory Postdoctoral Fellow (May 2008 – Jun. 2010)
  • Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan Postdoctoral Fellow (Feb. 2008 - Apr. 2008)
Endstation：
  • TPS 35A2 (Under Construction)
Research Interests：
  • We have built a set that contains matrix-assisted laser desorption / ionization (MALDI) coupled with an orthogonal acceleration time-of-flight mass spectrometer (OA-TOF-MS). Using synchrotron radiation light source with tunable soft X-ray to excite specific atom of a biological molecules, the core electron is stimulate to a particular molecular orbital followed by ionization and fragmentation simultaneously. The composition of the ionic fragments and some other features will be obtained by utilizing time-of-flight mass spectrometer. Using this method and the knowledge of element- and site-specific properties learned by other scientists, we are going to obtain the specificity of selective bond dissociation of bio-molecules (especially carbohydrates) from mass spectra. The analyzed data will be utilized to help determine the structure of important biological macromolecules such as carbohydrates through a series research of biological molecules. The short-term goal is to study the selectivity of bond breaking for small biological molecules/sugar-based molecules and to look for bio-molecular mass characteristics of selective bond breaking by comparing the mass spectra of different positions of excited oxygen atoms or carbon atoms.
Selected Publications：
  • Tse-Fu Shen, Yu-Ju Chiang, Yi-Shiue Lin, Chen-Lin Liu,* Yu-Chiao Wang, Kuan-Yi Chou, Cheng-Cheng Tsai and Wei-Ping Hu,* “Near-Edge X-Ray Absorption Fine-Structure Spectra and Specific Dissociation of Phe-Gly and Gly-Phe”, Int. J. Mol. Sci. 26, 2515 (2025).
  • Yu-Ju Chiang, Wan-Chou Huang, Chou-Hsun Han, Chen-Lin Liu*, Cheng-Cheng Tsai, and Wei-Ping Hu,* “Near-edge X-ray Absorption Fine Structure Spectra and Specific Dissociation of Small Peptoid Molecules”, J. Chem. Phys. 160, 074305 (2024).
  • Meirong Zeng, Chen-Lin Liu, and Kevin R. Wilson*, “Catalytic Coupling of Free Radical Oxidation and Electrophilic Chlorine Addition by Phase-Transfer Intermediates in Liquid Aerosols”, J. Phys. Chem. A, 126, 2959–2965 (2022).
  • Yao-Te Wang, Yu-Ju Chiang, and Chen-Lin Liu*, “Resolved specific dissociation channel of a core-excited peptide model molecule”, Chem. Phys. Lett., 759, 137967 (2020).
  • Yu-Ju Chiang, Wan-Chou Huang, Chi-Kung Ni, Chen-Lin Liu*, Cheng-Cheng Tsai, and Wei-Ping Hu*, “NEXAFS spectra and specific dissociation of oligo-peptide model molecules”, AIP Advances, 9, 085023 (2019).
  • Yu-Ju Chiang, Yi-Shiue Lin, Huei-Ru Lin, and Chen-Lin Liu*, “Specific Dissociation of Core-Excited Pyrimidine Nucleobases”, Chem. Phys. Lett., 706, 215 - 222 (2018).
  • Cheng-Cheng Tsai, Jien-Lian Chen, Wei-Ping Hu,* Yi-Shiue Lin, Huei-Ru Lin, Tsai-Yun Lee, Yuan T. Lee, Chi-Kung Ni, and  Chen-Lin Liu*, “Selectivity of Peptide Bond Dissociation on Excitation of a Core Electron: Effects of a Phenyl Group”, Chem. Phys. Lett. , 660, 60 - 68 (2016).
  • Denisia M. Popolan-Vaida, Chen-Lin Liu, Theodora Nah, Kevin R. Wilson, and Stephen R. Leone,* “Reaction of Chlorine Molecules with Unsaturated Submicron Organic Particles”, Z. Phys. Chem., 229, 1521 - 1540 (2015).
  • Yi-Shiue Lin, Huei-Ru Lin, Wei-Lun Liu, Yuan T. Lee, Chien-Ming Tseng, Chi-Kung Ni, Chen-Lin Liu*, Cheng-Cheng Tsai, Jien-Lian Chen, and Wei-Ping Hu*, “Near-Edge X-ray Absorption Fine Structure Spectra and the Dissociation Following the Core Excitation of Pyrimidine and Purine”, Chem. Phys. Lett. , 636, 146 - 153 (2015).
  • Yi-Shiue Lin, Cheng-Cheng Tsai, Huei-Ru Lin, Tsung-Lin Hsieh, Jien-Lian Chen, Wei-Ping Hu,* Chi-Kung Ni,* and Chen-Lin Liu*, “Highly Selective Peptide-Bond Dissociation Following Core Electron Excitations”, J. Phys. Chem. A, 119, 6195 - 6202 (2015).
  • Yi-Shiue Lin, Shu-Yu Lin, Yuan T. Lee, Chien-Ming Tseng, Chi-Kung Ni, Chen-Lin Liu,* Cheng-Cheng Tsai, Jien-Lian Chen, and Wei-Ping Hu*, “Core Excitation, Specific Dissociation and the Effect of the Size of Aromatic Molecules Connected to Oxygen: Phenyl Ether and 1,3-Diphenoxybenzene”, J. Phys. Chem. A, 118, 7803 - 7815 (2014).
  • Yi-Shiue Lin, Kun-Ta Lu, Yuan T. Lee, Chien-Ming Tseng, Chi-Kung Ni, and Chen-Lin Liu*, “Near-Edge X-ray Absorption Fine Structure Spectra and Site-Selective Dissociation of Phenol”, J. Phys. Chem. A, 118, 1601 - 1609 (2014).
  • Yi-Shiue Lin, Shu-Yu Lin, Yuan T. Lee, Chien-Ming Tseng, Chi-Kung Ni, Chen-Lin Liu*, Cheng-Cheng Tsai, Jien-Lian Chen, and Wei-Ping Hu*, “Core Excitation, Specific Dissociation and the Effect of the Size of Aromatic Molecules Connected to Oxygen: Phenyl Ether and 1,3-Diphenoxybenzene”, J. Phys. Chem. A, 118, 7803 - 7815 (2014).
  • S. Soorkia, Chen-Lin Liu, J. D. Savee, S. J. Ferrell, M. Ahmed, S. R. Leone and K. R. Wilson*, “Airfoil sampling of a pulsed Laval beam with tunable vacuum ultraviolet (VUV) synchrotron ionization quadrupole mass spectrometry: Application to low-temperature kinetics and product detection”,Review of Scientific Instruments, 82, 124102 (2011).
  • C. Koh, Chen-Lin Liu, C. Harmon, D. Strasser, A. Golan, O. Kostko, S. D. Chambreau, G. L.Vaghjiani, and S. R. Leone*, “Soft ionization of thermally evaporated hypergolic ionic liquid aerosols”, J. Phys. Chem. A, 115, 4630 – 4635 (2011).
  • Chen-Lin Liu, J. D. Smith, D. L. Che, M. Ahmed, S. R. Leone, and K. R. Wilson*, “The Direct Observation of Secondary Radical Chain Chemistry in the Heterogeneous Reaction of Chlorine Atoms with Submicron Squalane Droplets”, Phys. Chem. Chem. Phys., 13, 8993 - 9007 (2011).