About NSRRC / Staff Directory

Life Science Group

Name: 黃佩瑜( Pei-Yu Huang )
EXT.: 7329
E-mail: pyhuang@nsrrc.org.tw
  • M.S. in Biomedical Engineering, National Cheng kung University (2003~2005)
  • National Synchrotron Radiation Research Center Assistant Research Fellow (2024~present)
  • National Synchrotron Radiation Research Center Research Assistant (2006 - 2023)
  • End-station of Infrared Microspectroscopy, BL14A1
  • Beamline Manger
Research Interests:
  • Study of the innovative method of wax physisorption kinetics (WPK) for detecting altered glycosylation for early detection of cancer.
  • Using synchrotron-based FTIR imaging for diagnosing chronic disease and assessing transplanted tissue.
  • Vibrational spectroscopy of fossil using synchrotron-based FTIR microspectroscopy and Confocal Raman microscopy.
Patent: 發明專利 •    Y.-C. Lee, P.-Y. Huang and C.-I. Chen, Method for detecting cancer and reagents for use therein,   USA patent, US-8-354,222 B2 (2013) •    李耀昌、黃佩瑜、陳慶曰, “癌化生物標本の検出方法、および、使用する検査試薬”, 日本專利, 特許第5266556號 (2013) •    李耀昌、黃佩瑜、陳慶曰, “癌化生物樣品之檢測方法及其使用之檢測試劑”, 臺灣專利, 第 I 404931號 (2013). •    李耀昌,黃佩瑜, “鑑定癌級別之方法“,臺灣專利, 第 I 685661號 (2020) •    Y.-C. Lee, P. -Y. Huang, “Method for Cancer Grading“, European Patent Application, EP3578982 (2020)   (German 602018008644.7; UK 3578982; France 3578982) •    Y.-C. Lee, P. -Y. Huang,「癌グレーディングのための方法」, Japan patent,特許第6782818號 (2020) •    Y.-C. Lee, P.-Y. Huang, Method for Cancer Grading, USA patent, US 10,948,482 B2, (2021) 新型式專利 •    李耀昌,黃佩瑜 “一種新型顯微鏡照明裝置”臺灣專利, 第09,840,927,640 (2009)   •    Y.-C. Lee and P. -Y. Huang, “A novel microscope illuminator”, Japan Patent No. 3150912 (2009)
Selected Publications:
  • L.-F. Chiu, P.-Y. Huang, W.-F. Chiang, T.-Y. Wong, S.-H. Lin, Y.-C. Lee*, D.-B. Shieh*, “Oral cancer diagnostics based on infrared spectral markers and wax physisorption kinetics”, Anal. Bioanal. Chem., 405(6), 1995 (2013) (IF: 4.3)
  • P.-Q Yu, K. Theodoridou, H. Xin, P.-Y. Huang, Y.-C. Lee, B. R. Wood, “Synchrotron-based microspectroscopic study on the effects of heat treatments on cotyledon tissues in yellow-type canola (Brassica) seeds. “J. Agric. Food Chem., 61, 7234(2013) (IF: 6.1)
  • M. M. H. Hsu, P.-Y. Huang, Y.-C. Lee, Y.-C. Fang, M. W. Y. Chan, and C.-I Lee*, “FT-IR Microspectrometry Reveals the Variation of Membrane Polarizability due to Epigenomic Effect on Epithelial Ovarian Cancer.”, Int J Mol Sci.,15(10): 17963, (2014) (IF:5.6)
  • C-H. Lee, C-Y. Hsu, P-Y. Huang, C-I. Chen, Y-C. Lee*, and H-S. Yu*, “Arsenite Regulates Prolongation of Glycan Residues of Membrane Glycoprotein: A Pivotal Study via Wax Physisorption Kinetics and FTIR Imaging”, Int. J. Mol. Sci. (2016), 17(3), 427. (IF:5.6)
  • Y.-C. Lee*, C.-C. Chiang, P.-Y. Huang, C.-Y. Chung, T. D. Huang, C.-C. Wang, C.-I. Chen, R.-S. Chang, C.-H. Liao, R. R. Reisz*, “Evidence of preserved collagen in an Early Jurassic sauropodomorph dinosaur revealed by synchrotron FTIR microspectroscopy”, Nat. Commun., 8, 14220, (2017). (IF:16.6)
  • E. K. Astani, S. Ersali, Y.-C. Lee, P.-J. Lin, Y.-C. Huang, P.-Y. Huang, V. Jafarian, S. Hosseinkhani, C.-J. Chen*,” Determination and evaluation of secondary structure content derived from calcium-induced conformational changes in wild-type and mutant mnemiopsin 2 by synchrotron-based Fourier-transform infrared spectroscopy”, Biochim. Biophys. Acta - Proteins Proteom., 1868, 140528 (2020) (IF:3.2)
  • K. Lakshmanan, W.-H. Huang, S. A. Chala, B. W. Taklu, E. A. Moges, J.-F. Lee, P.-Y. Huang, Y.-C. Lee, M.-C. Tsai*, W.-N. Su*, and B. J. Hwang*, “Highly Active Oxygen Coordinated Configuration of Fe Single-atom Catalyst toward Electrochemical Reduction of CO2 into Multi-carbon Products”, Adv. Funct. Mater., 32, 2109310 (2022) (IF:19.0)
  • A. A. Ayele, M.-C. Tsai*, D. B. Adam, Y. A. Awoke, W.-H. Huang, C.-Y. Chang, S.-C. Liao, P.-Y. Huang, J.-L. Chen, C.-W. Pao, W.-N. Su*, and B. J. Hwang*, “Electrochemical Oxidation of Ethylene Glycol on TiO2-supported Platinum Single-atom Catalyst into Valuable Chemicals in Alkaline Media”, Appl. Catal. A-Gen., 646, 118861, (2022) (IF: 5.5) 
  • P.-Y. Lin, P.-Y. Huang, Y.-C Lee* and C.-S. Ng*, “Analysis and comparison of protein secondary structures in the rachis of avian flight feathers”, PeerJ, 10:e12919 (2022) (IF: 2.7)
  • Y.-T.Chen, P.-Y.Huang, J.-Y.Wang, Y.-C. Lee* and C.-Y. Chai*, “An innovative diagnosis in gastrointestinal neuroendocrine neoplasms using Wax-Physisorption-Kinetics-based FTIR Imaging.“ Sci. Rep., 12, 17168(2022) (IF: 4.6) 
  • P.- L. Chen, T. -Y. Chang, P. -S. Chen, A. H. -Y. Chan, A. S. Rosyadi, Y. -J. Lin, P.-Y. Huang, J. -X. Li, W. -Q Li, C. -J Hsu, N. Na, Y.-C. Lee, C. –H. Ho, C. -H. Liu*, “Van der Waals heterostructure mid-infrared emitters with electrically controllable polarization states and spectral characteristics. ACS nano, 17(11), 10181-10190, (2023) (IF: 17.1)
  • Y.-T. Chen#, P.-Y. Huang#, C.-Y. Chai, S. Yu, Y.-L. Hsieh, H.-C. Chang, C.-W. Kuo, Y.-C. Lee*, and H.-S. Yu*, “Early detection of the initial stages of LED light-triggered non-alcoholic fatty liver disease by wax physisorption kinetics-Fourier transform infrared imaging”, Analyst, 2023, 148, 643 - 653 (IF: 4.2)
  • K. Lakshmanan, , W. -H. Huang, S. A. Chala,, C. -Y. Chang, S. T. Saravanan,, B. W. Taklu, C.-Y. Chang, S. T. Saravanan, B. W. Taklu, E. A. Moges, Y. Nikodimos, B. D. Dandena, S. -C. Yang, J. -F. Lee, P. -Y. Huang, Y. -C. Lee, M. -C. Tsai, W. -N. Su, B. -J. Hwang, “Generating Multi‐Carbon Products by Electrochemical CO2 Reduction via Catalytically Harmonious Ni/Cu Dual Active Sites”., Small, 2307180 (2023) ( IF: 13.3)
  • Y-C. Lee, C-I. Chen, P-Y. Huang, and C-Y. Liu, “A study of Fourier-Transform infrared Microspectroscopy under Top-Up injection Operation at NSRRC”, Instruments today.170, 7-15 (2009)
  • Y-C. Lee, P-Y. Huang, Y-C. Chang and C-I. Chen, “An infrared kinetic study of wax physisorption for oral cavity cancer detection using synchrotron-based infrared microspectrscopy”, Instruments today.170, 47-60 (2009) 
  • 李耀昌、陳俊榮、馮學深、李志甫、黃玉山、李明道、宋豔芳、鄭有舜、江素玉、陳慶曰、黃佩瑜、許益瑞、俞聖法、吳文桂, “同步輻射在生命科學上的應用與發展-高解析傅立葉轉換紅外光譜顯微術原理與應用”, 物理雙月刊(三十卷一期) 2008 年二月
  • 江正誠、黃佩瑜、李耀昌, “台灣科學神燈下的恐龍世界”, 科學發展, 2015,10, 514 期
  • 江正誠、黃佩瑜、陳慶曰、李耀昌, “探索恐龍化石的顯微世界”, 科儀新知, 2015,12, 205期