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Education：
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- Ph.D., Institute of Biochemistry and Molecular Biology, Yang-Ming University, Taiwan (2008)
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Experience：
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- Assistant Scientist, National Synchrotron Radiation Research Center (2015-)
- Associate Research Fellow, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China (2010-2014)
- Postdoctoral Fellow, Genomics Research Center, Academia Sinica (2009-2010)
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Endstation：
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- BL13B1，BL13C1, BL15A1 and TPS 05A
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Research Interests：
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- X-ray crystallography and structural biology
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Selected Publications：
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- Chan HC, Ko TP, Huang CH and Guo RT. Minireviw: A comeback of Hg-derivatives in protein crystallography with Cys-modification. ChemBioEng Rev. (2015) 2: 133-140
- Huang CH, Zhen Z, Cheng YS, Chan HC, Ko TP, Chen CC, Wang I, Ho MR, Hsu ST, Zeng YF, Huang YN, Liu JR and Guo RT. Structure and catalytic mechanism of a glycoside hydrolase family-127 β-L-arabinofuranosidase (HypBA1). Journal of Bioprocessing & Biotechniques (2014) in press
- Chan HC, Feng X, Ko TP, Huang CH, Hu Y, Zheng Y, Bogue S, Nakano C, Hoshino T, Zhang L, Lv P, Liu W, Crick DC, Liang PH, Wang AH, Oldfield E, and Guo RT. Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. J Am Chem Soc. (2014) 136:2892-2896
- Cheng YS, Huang CH*, Chen CC, Huang TY, Ko TP, Huang JW, Wu TH, Liu JR, and Guo RT. Structural and mutagenesis analyses of a 1,3-1,4-β-glucanase from Paecilomyces thermophile. Biochim Biophys Acta. (2014) 1844:366-373. (*co-first author)
- Huang CH, Sun Y, Ko TP, Chen CC, Zheng Y, Chan HC, Pang X, Wiegel J, Shao W, and Guo RT. The substrate/product-binding modes of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485. Biochem. J. (2012) 448:401-407
- Liu W, Sun Y, Ko TP, Weigel J, Shao W, Guo RT, and Huang CH. Crystallization and preliminary X-ray diffraction analysis of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485. Acta Crystallogr Sect F Struct Biol Cryst Commun. (2012) F68: 914-16
- Ren F, Ko TP, Feng X, Huang CH, Chan HC, Hu Y, Wang K, Ma Y, Liang PH, Wang AH, Oldfield E, and Guo RT. Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes. Angew.Chem Int. (2012) 51(17):4157-60
- Wu TH, Huang CH*, Ko TP, Lai HL, Ma Y, Chen CC, Cheng YS, Liu JR, Guo RT. Diverse substrate recognition mechanism revealed by Thermotoga maritime Cel5A structures in complex with cellotetraose, cellobiose and mannotriose. Biochim Biophys Acta. (2011) 1814(12):1832-40 (*co-first author)
- Huang CH, Winkler A, Chen CL, Lai WL, Tsia YC, Macheroux P, Liaw SH. Functional roles of the 6-S-cysteinyl, 8α-N1-histidyl FAD in glucooligosaccharide oxidase from Acremonium strictum. J Biol Chem. (2008) 283(45):30990-6
- Huang CH, Lai WL, Lee MH, Chen CJ, Vasella A, Tsai YC, Liaw SH. Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8α-N1-histidyl FAD. J Biol Chem. (2005) 280(46):38831-8
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