About NSRRC / Staff Directory

Life Science Group

Name: 李耀昌( Yao-Chang Lee )
EXT.: 7333
E-mail: yclee@nsrrc.org.tw
  • Ph.D. in Chemistry, National Tsing Hua University (2002)
  • Associate research scientist Research Scientist National Synchrotron Radiation Research Center (1/ 2018~present)
  • Assistant research scientist National Synchrotron Radiation Research Center (1/ 2004~12/2017)
  • Adjunct Associate professor, Department of Chemistry, National Tsing Hua University (2/2020~present)
  • Adjunct Associate professor, Department of Optics and Photonics, National Central University (8/2019~present)
  • Adjunct Assistant professor, Department of Optics and Photonics, National Central University (8/2014~present)
  • Adjunct Assistant professor, Department of Applied Science, National Hsinchu University of Education (8/2003~7/2012)
  • Researcher, Industrial Technology Research Institute (8/2002~12/2003)
Research Interests:
  • Developing wax physisorption kinetics (WPK) for detecting aberrant glycosylation of early detection of cancer and chronic disease.
  • Establishing artificial intelligence algorithms based on FTIR-WPK imaging data by using VB.NET  in Disease Diagnosis.
  • Developing assessment strategies of transplanted tissue by using WPK-FTIR imaging
  • Composition analysis of paleontological samples using synchrotron-based FTIR microspectroscopy and Confocal Raman microscopy
  • Y.-C. Lee (李耀昌), P. Y. Huang, C.-I. Chen, “Method for detecting cancer and reagents for use therein”, R.O.C. patent, No. 404931, (2013); Japan patent, 2009-119309, (2013); USA patent, US-8-354,222 B2, (2013). 2017年授權予民間第三方公司,2017~2019技轉
  • Y.-C. Lee (李耀昌), P. Y. Huang, “Method for Cancer Grading“, R.O.C. patent, No. 107145326 (2020); Japan patent, P6782818(2020); European Patent Application, EP3578982 (2020) (German 602018008644.7; UK 3578982; France 3578982); USA patent, US 10,948,482 B2, (2021) 
  1. Y.-C. Lee and H.-W. Wang, “Real-time infrared chemical imaging spectrometer”, R.O.C. Patent, No. 203,435 (2004).
  2. Y.-C. Lee (李耀昌), “Metal-recognized apparatus and methodology by optical reflection”, R.O.C. Patent, No. I226, 435 (2005).
  3. Y.-C. Lee (李耀昌), “Multi-reflection collection probe of Fluorescence inspection”, R.O.C. Patent, No. I230, 789 (2005).
  4. Y.-C. Lee (李耀昌) and H.-W. Wang, “Real-Time infrared chemical imaging spectroscopic apparatus”, USA patent, US 6992293 B2 (2006)
  5. Y.-C. Lee (李耀昌) and P.-Y. Huang, “A novel microscope illuminator “, R.O.C. Patent, No. 09840927640(2009), Japan Patent, No. 3150912 (2009)
  6. Y.-C. Lee (李耀昌), P. Y. Huang, C.-I. Chen, Method for detecting cancer and reagents for use therein, USA patent, US-8-354,222 B2, (2013) ; Japan patent, 2009-119309, (2013) ; R.O.C. patent, No. 404931, (2013). The patent of WPK has been licensed to a third-party company in 2017.
  7. Y.-C. Lee (李耀昌), P. Y. Huang, “Method for Cancer Grading“, US 16/002,538(pending); EP18179385.2 (2018)(pending)
Selected Publications:
  • Y.-H. Hsieh, J.-H. Zhang, W.-C. Chuang, K.-H. Yu, X.-B. Huang, Y.-C. Lee (李耀昌), and C.-I. Lee*, “An in Vitro Study on the Effect of Combined Treatment with Photodynamic and Chemical Therapies on Candida Albicans”, Int. J. Mol. Sci. 19, 337 (2018) (IF: 5.57) (citation: 44)
  • Priprem, Y.-C. Lee (李耀昌), W. Limphirat, S. Tiyaworanant, K. Saodaeng, J. Chotitumnavee, N. Kowtragoon, “Eucalyptus ash alters secondary protein conformation of human grey hair and facilitates anthocyanin dyeing” PLoS ONE, 13, 7, e0199696(2018) https://doi.org/10.1371/journal.pone.0199696 (IF: 3.7) (citation:3)
  • L. J. Bancin, B. A. Walther, Y.-C. Lee (李耀昌), A. Kunz, “Two-dimensional distribution and abundance of micro- and mesoplastic pollution in the surface sediment of Xialiao Beach, New Taipei City, Taiwan”, Mar. Pollut. Bull., 140, 75–85 (2019) (IF: 5.8) (citation: 59)
  • J. Rathod, J.-S. Jean, W.-T. Jiang, I-H. Huang, B. H. Liu, Y.-C. Lee (李耀昌), “Micro-colonization of arsenic-resistant Staphylococcus sp. As-3 on arsenopyrite (FeAsS) drives arsenic mobilization under anoxic sub-surface mimicking conditions”, Sci. Total Environ., 669, 527–539 (2019) (IF: 9.8) (citation: 20)
  • W.-J. Syu, C.-C. Huang, J.-K. Hsiao, Y.-C. Lee (李耀昌), Y.-T. Huang, P. Venkatesan, P.-S. Lai, “Co-precipitation Synthesis of Near-infrared Iron Oxide Nanocrystals on Magnetically Targeted Imaging and Photothermal Cancer Therapy via Photoablative Protein Denature”, Nanotheranostics, 3, 236 (2019) (IF: 4.8) (citation: 17)
  • Y.-T. Weng, J. Rathod, B. Liang*, C.-C. Wang, Y. Iizuka, N. Tamura, C.-L. Chen, Y.-C. Lee (李耀昌), “Black carbon enriches short-range-order ferrihydrite in Amazonian Dark Earth: Interplay mechanism and environmental implications”, Sci. Total Environ., 725,10, 138195 (2020) (IF: 9.8) (citation: 6)
  • I.-M. Lin, C.-M. Chou, M.-C. Li, R.-H. Guo, C.-K. Lee, H.-J. Li, Y.-W. Chiang, Y.-H. Lin, Y.-C. Lee (李耀昌), C.-J. Su, U.-S. Jeng, W.-T. Chuang*, “Superhelices with tunable twisting power directed from supramolecular pairing of focal asymmetry in achiral dendron‐jacketed block copolymers” J. Mater. Chem. C, 8, 1923-1932 (2020) (IF: 6.4) (citation: 8)
  • Y.-L. Cho, Y.-C. Lee (李耀昌), L.-C. Hsu, C.-C. Wang, P.-C. Chen, S.-L. Liu, H.-Y. Teah, Y.-T. Liua, Y.-M. Tzoua, “Molecular mechanisms for Pb removal by Cyanidiales: a potential biomaterial applied in thermo-acidic conditions”, Chem. Eng. J., 401, 125828 (2020) (IF: 16.744) (citation: 16)
  • P. P. Biswas, B. Liang*, G. Turner-Walker 2, J. Rathod, Y.-C. Lee (李耀昌), C.-C. Wang, C.-K. Chang, “Systematic Changes of Bone Hydroxyapatite along a Charring Temperature Gradient: An integrative Study with Dissolution Behaviour”, Sci. Total Environ., 766, 142601(2021) (IF: 9.8) (citation: 21)
  • R.-H. Guo, C.-M. Chou, C.-C. Wang, M.-J. Deng, J.-M. Lin, C.-Y. Chen, Y.-C. Lee (李耀昌), Y.-W. Chiang, W.-T. Chuang, “Biomimetic strategies for 4.0 V all-solid-state flexible supercapacitor: Moving toward eco-friendly, safe, aesthetic, and high-performance devices”, Chem. Eng. J., 414, 128842 (2021) (IF: 16.744) (citation: 9)
  • S,-W. Chang, R.-G. Chen, T.-H. Liu, Y.-C. Lee (李耀昌), C.-S. Chen, T.-S. Chiu and C.-Y. Ko, “Dietary Shifts and Risks of Artifact Ingestion for Argentine Shortfin Squid Illex argentinus in the Southwest Atlantic”, Front. Mar. Sci., 8:675560 (2021). DOI: 10.3389/fmars.2021.675560 (IF: 5.247) (citation: 1)
  • K. Lakshmanan, W.-H. Huang, S. A. Chala, B. W. Taklu, E. A. Moges, J.-F. Lee, P.-Y. Huang, Y.-C. Lee (李耀昌), M.-C. Tsai*, W.-N. Su*, and B. J. Hwang*, “Highly Active Oxygen Coordinated Configuration of Fe Single-atom Catalyst toward Electrochemical Reduction of CO2 into Multi-carbon Products”, Adv. Funct. Mater., 32, 2109310 (2022) (IF: 19.924) (citation: 34)
  • P. P. Biswas, G. Turner-Walker, J. Rathod, B. Liang*, C.-C. Wang, Y.-C. Lee (李耀昌), and H.-S. Sheu, “Sustainable Phosphorus Management in Soil Using Bone Apatite”, J. Environ. Manage 305, 114344 (2022) (IF: 8.7) (citation: 7)
  • E.-L. Cho, Y.-M. Tzou, C.-C. Wang, Y.-C Lee (李耀昌), L.-C. Hsu, S.-L. Liu, A. Assakinah, Y.-H. Chen, N. A. T. Than, Y.-T. Liu*, J. Rinklebe, “Removal and concurrent reduction of Cr(VI) by thermo-acidophilic Cyanidiales: a novel extreme biomaterial enlightened for acidic and neutral conditions”, J. Hazard. Mater., 130334, ISSN 0304-3894 (2022), DOI: https://doi.org/10.1016/j.jhazmat.2022.130334 ( IF: 13.6) (citation: 5)
  • P.-Y. Lin, P.-Y. Huang, Y.-C Lee* (李耀昌) and C.-S. Ng*, “Analysis and comparison of protein secondary structures in the rachis of avian flight feathers”, PeerJ, 10:e12919 (2022), DOI: http://doi.org/10.7717/peerj.12919 ( IF: 3.06) (citation: 4)
  • Y.-T.Chen, P.-Y.Huang, J.-Y.Wang, Y.-C. Lee* (李耀昌) and C.-Y. Chai*, “An innovative diagnosis in gastrointestinal neuroendocrine neoplasms using Wax-Physisorption-Kinetics-based FTIR Imaging.“ Sci. Rep., 12, 17168 (2022). DOI: https://doi.org/10.1038/s41598-022-22221-0 ( IF: 4.6)
  • Y.-L. Cho, Y.-M. Tzou, C.-C. Wang, Y.-C. Lee (李耀昌), L.-C. Hsu, S.-L. Liu, A. Assakinah, Y.-H. Chen, N. A. T. Than, Y.-T. Liu*, J. Rinklebe, "Removal and Concurrent Reduction of Cr(VI) by Thermoacidophilic Cyanidiales: a Novel Extreme Biomaterial Enlightened for Acidic and Neutral Conditions", J. Hazard. Mater. 445, 130334 (2023) ( IF: 13.6) (citation: 5)
  • C-T Chiu, J.-K. Cao, P.-W. Wang, Y.-N. Wu, Y.-C. Lee (李耀昌), Y.-R. Jeng*, D.-B. Shieh*, R. R. Reisz*, “Mammalian tooth enamel functional sophistication demonstrated by combined nanotribology and synchrotron radiation FTIR analyses”, iScience, 26, 105679 (2023) ( IF: 6.107 ) (citation: 1)
  • Y.-T. Chen, P.-Y. Huang, C.-Y. Chai, S. Yu, Y.-L. Hsieh, H.-C. Chang, C.-W. Kuo, Y.-C. Lee* (李耀昌), and H.-S. Yu*,“Early detection of the initial stages of LED light-triggered non-alcoholic fatty liver disease by wax physisorption kinetics-Fourier transform infrared imaging”,  Analyst, 148(3), 643-653 (2023)  (IF: 5.227)