| 代表作：
|
For the complete list, please go to
https://orcid.org/0000-0002-5157-4288 or
https://scholar.google.com.tw/citations?hl=zh-TW&user=oTFF8K0AAAAJ&view_op=list_works&sortby=pubdate or
https://www.researchgate.net/profile/Chun-Jung-Chen-3
- Hsieh, Y.-C., Guan, H.-H., Lin, C.-C., Huang, T.-T., Chuankhayan, P., Chen, N.-C., Wang, N.-H., Hu, P.-L., Tsai, Y.-C., Huang, Y.-C., Yoshimura, M., Lin, P.-J., Hsieh, Y.-H.*,
Chen, C.-J.* “A structure-based high-efficiency homogeneous antibody platform by endoglycosidase Sz provides insights into its transglycosylation mechanism”. JACS Au,
2024, 4, 2130–2150.
- Chiang, W. T., Chang, Y.-K., Hui, W.-H., Chang, S.-W., Liao, C.-Y., Chang, Y.-C.,
Chen, C.-J., Wang, W.-C., Lai, C.-C., Wang, C.-H., Luo, S.-Y., Huang, Y.-P., Chou, S.-H., Horng, T.-L., Hou, M.-H., Muench, S. P., Chen, R.-S., Tsai, M.-D.*, Hu, N.-J.* “Structural basis and synergism of ATP and Na+ activation in bacterial K+ uptake system KtrAB”. Nature Commun. 2024, 15, 3850.
- Mathimaran, A., Nagarajan, H., Mathimaran, A., Huang, Y.-C., Chen, C.-J., Vetrivel, U., Jeyaraman, J.* “Deciphering the pH-dependent oligomerization of aspartate semialdehyde dehydrogenase from Wolbachia endosymbiont of Brugia malayi: An in vitro and in silico approaches”. Int. J. Biol. Macromol. 2024, 276, 133977.
- Chen, N.-C., Wang, C.-H., Yoshimura, M., Yeh, Y.-Q., Guan, H.-H., Chuankhayan, P., Lin, C.-C., Lin, P.-J., Huang, Y.-C., Wakatsuki, S., Ho, M.-C.*, Chen, C.-J.* “Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions”. Nature Commun. 2023, 14: 545.
- Chuankhayan, P., Lee, R.-H., Guan, H.-H., Lin, C.-C., Chen, N.-C., Huang, Y.-C., Yoshimura, M., Nakagawa, A., Chen, C.-J.* “Structural insight into the hydrolase and synthase activities of an alkaline α-galactosidase from Arabidopsis from complexes with substrate/product”. Acta Cryst. 2023, D79, 154–167.
- Chan, S. I.*, Chuankhayan, P., Nareddy, Pavan K., Tsai, I-K., Tsai, Y.-F., Chen, K. H.-C., Yu, S. S.-F.*,
Chen, C-J.* “The mechanism of PQQ-dependent hydride transfer chemistry from spectroscopic and high-resolution X-ray structural studies of the methanol dehydrogenase from Methylococcus capsulatus (Bath)”. J. Am. Chem. Soc.
2021, 143, 9, 3359–3372.
- Guan, H.-H., Huang, Y.-H. Lin, E.-S., Chen, C.-J.*, Huang, C.-Y.* “Plumbagin, a natural product with potent anticancer activities, binds to and inhibits dihydroorotase, a key enzyme in pyrimidine biosynthesis”. Int. J. Mol. Sci. 2021, 22(13), 6861.
- Guan, H.-H., Huang, Y.-H. Lin, E.-S., Chen, C.-J.*, Huang, C.-Y.* “Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil”. Biochem. Biophys. Res. Commun.
2021, 551, 33–37.
- Guan, H. H., Huang, Y. H., Lin, E. S., Chen, C.-J.*, Huang, C.-Y.* “Structural analysis of Saccharomyces cerevisiae dihydroorotase reveals molecular insights into the tetramerization mechanism”. Molecules,
2021, 26, 7249.
- Guan, H.-H., Huang, Y.-H. Lin, E.-S., Chen, C.-J.*, Huang, C.-Y.* “Complexed crystal structure of Saccharomyces cerevisiae dihydroorotase with inhibitor 5-fluoroorotate reveals a new binding mode”. Bioinorg. Chem. Appl. 2021,
2021, 2572844.
- Astani, E. K, Ersali, S., Lee, Y.-C., Lin, P.-J., Huang, Y.-C., Huang, P.-Y., Jafarian, V., Hosseinkhani, S*,
Chen, C.-J.* “Determination and evaluation of secondary structure content derived from calcium-induced conformational changes in wild-type and mutant mnemiopsin 2 by synchrotron-based Fourier-transform infrared spectroscopy”. Biochim. Biophys. Acta–protein and Proteomics, 2020, 1868(12), 140528.
- Chen, S.-K. Guan, H.-H., Wu, P.-H., Lin, L.-T., Wu, M.-C., Chang, H.-Y., Chen, N.-C., Lin, C.-C., Chuankhayan, C., Huang, Y.-C., Lin, P.-J.,
Chen, C.-J.* “Structural insights into histidine-containing phosphotransfer protein and receiver domain of sensor histidine kinase suggest a complex model in two-component regulatory system in Pseudomonas aeruginosa”. IUCrJ,
2020, 7, 934–948.
- Yoshimura, M., Chen, N.-C., Guan, H.-H., Chuankhayan, P., Lin, C.-C., Nakagawa, A.,
Chen, C.-J.* “Non-crystallographic symmetry constraint map obtained by direct density optimization”. Acta Cryst.
2020, D76, 147–154.
- Astani, E. K., Chen, N.-C. Huang, Y.-C., Ersali, S., Lin, P.-J., Guan, H.-H., Lin, C.-C., Chuankhayan, P.,
Chen, C.-J.* “Characterization of dimeric interactions within protrusion-domain interfaces of parallel and X-shaped conformations of Macrobrachium rosenbergii nodavirus: a theoretical study using the DFT method along with QTAIM and NBO analyses”. ACS Omega, 2020, 5, 3428–3443.
- Chen, N.-C., Yoshimura, Naoyuki Miyazaki, M.Guan, H.-H., Chuankhayan, P., Lin, C.-C., Chen, S.-K., Lin, P.-J., Huang, Y.-C., Iwasaki, K., Nakagawa, A., Chan, S. I.,
Chen, C.-J.* “The atomic structures of shrimp nodaviruses reveal new dimeric spike structures and particle polymorphism”. Commun. Biol.
2019, 2:72.
- Guan, H.-H., Hsieh, Y.-C., Lin, P.-J., Huang, Y.-C. Yoshimura, M., Chen, L.-Y., Chen, S.-K., Chuankhayan, P., Lin, C.-C., Chen, N.-C., Nakagawa, A., Chan, S. I.,
Chen, C.-J.* “Structural insights into the electron/proton transfer pathways in the quinol:fumarate reductase from Desulfovibrio gigas”. Sci. Rep.
2018, 8:14935.
- Chen, L.-Y., Huang, Y.-C., Huang, S.-T., Hsieh, Y.-C., Guan, H.-H., Chen, N.-C., Chuankhayan, P., Yoshimura, M., Tai, M.-H.*,
Chen, C.-J.* “Domain swapping and SMYD1 interactions with the PWWP domain of human hepatoma-derived growth factor”. Sci. Rep. 2018, 8(1): 287.
- Huang, Y.-H., Guan, H.-H., Chen, C.-J.*, Huang, C.-Y.* “Staphylococcus aureus single-stranded DNA-binding protein SsbA can bind but cannot stimulate PriA helicase”. PLoS ONE,
2017, 12, e0182060.
- Yoshimura, M., Chen, N.-C., Guan, H.-H., Chuankhayan, P., Lin, C.-C., Nakagawa, A., Chen, C.-J.* “Ab initio phasing by molecular averaging in real space with new criteria: application to structure determination of a betanodavirus”. Acta Cryst. 2016, D72, 830–840.
- Chiu, H.-H., Hsieh, Y.-C., Chen, Y.-H., Wang, H.-Y., Lu, C.-Y., Chen, C.-J.*, Li, Y.-K.* “Three important amino acids control the regioselectivity of flavonoid glucosidation in glycosyltransferase-1 from Bacillus cereus”. Appl. Microbiol. Biotechnol. 2016, 100, 8411–8422.
- Guan, H.-H. Yoshimura, M., Chuankhayan, P., Lin, C.-C., Chen, N.-C., Yang, M.-C., Ismail, A., Fun, H.-K.,
Chen, C.-J.* Crystal structure of an antigenic outer-membrane protein from Salmonella Typhi suggests a potential antigenic loop and an efflux mechanism”. Sci. Rep.
2015, 5:16441.
- Chen, N.-C., Yoshimura, M., Guan, H.-H., Wang, T.-Y., Misumi, Y., Lin, C.-C., Chuankhayan, P., Nakagawa, A., Chan, S. I., Tsukihara, T., Chen, T.-Y.*,
Chen, C.-J.* “Crystal structures of a piscine betanodavirus: mechanisms of capsid assembly and viral infection”. PLoS Path.
2015, 11(10): e1005203.
- Chen, K. H.-C., Chuankhayan, C., Wu, H.-H., Chen, C.-J.*, Fukuda, M., Yu, S. S.-F.*, Chan, S. I.* “The bacteriohemerythrin from Methylococcus capsulatus (Bath): Crystal structures reveal Leu114 regulates the substrate tunnel”. J. Inorg. Biochem. 2015, 15, 81–89.
- Lin, C.-C., Chuankhayan, P., Chang, W.-N., Kao, T.-T., Guan, H.-H., Fun, H.-K., Nakagawa, A., Fu, T.F.*,
Chen, C.-J.* “Crystal structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product Inhibition”. Acta Cryst.
2015, D71, 1006–1021.
- Chen, C.-D., Huang, Y.-C., Chiang, H.-L., Hsieh, Y.-C., Chuankhayan, P., Chen, C.-J.* “Direct phase selection of initial phases from single-wavelength anomalous dispersion (SAD) for the improvement of electron density and ab initio structure determination”. Acta Cryst. 2014, D70, 2331–2343.
- Praditwongwan, W, Chuankhayan, P., Saoin, S., Wisitponchai, T., Lee, V. S., Nangola, S., Hong, S. S., Minard, P., Boulanger, P.,
Chen, C.-J.*, Tayapiwatana, C.* “Crystal structure of an antiviral ankyrin targeting the HIV-1 capsid and molecular modeling of the ankyrin-capsid complex”. J. Comput. Mol. Des. 2014, 28, 869–884.
- Chuankhayan, P., Tao, T.-T., Lin, C.-C., Guan, H.-H., Nakagawa, A., Fu, T.-F.*,
Chen, C.-J.* “Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish γ-glutamyl hydrolase”. J. Med. Chem.
2013, 56, 7625–7635.
- Tien, Y.-C., Chuakhanyan, P., Huang, Y.-C., Chen, C.-D., Alikhajeh, J., Chang, S.-L.,
Chen, C.-J.* “Crystal structures of rice (Oryza sativa) glyceraldehyde-3-phosphate dehydrogenase complexes with NAD+ and sulfate suggests involvement of Phe37 in NAD+-specificity”. Plant Mol. Biol.
2012, 80, 389–403.
- Chen, C.-D., Lin, C.-H., Chuankhayan P., Huang, Y.-C., Hsieh, Y.-C., Huang, T.-F., Guan, H.-H., Liu, M.-Y., Chang, W.-C.,
Chen, C.-J.* “Crystal structures of complexes of the branched-chain aminotransferase from Deinococcus radiodurans with α-ketoisocaproate and L-glutamate suggest the radiation resistance of this enzyme for catalysis”. J Bacteriol.
2012, 194, 6206–6216.
- Fang, J.-Y., Chiang, Y.-L., Hsieh, Y.-C., Wang, V. C.-C., Huang, Y.-C., Chuankhayan, P., Liu, M.-Y., Chan, S. I.,
Chen, C.-J.* “Crystallization of adenylylsulfate reductase from Desulfovibrio gigas: A strategy based on controlled protein oligomerization”. Cryst. Growth & Des.
2011, 11, 2121-2134.
- Hsieh, Y.-C., Liu, M.-Y., Wang, V. C.-C., Chiang Y.-L., Liu, E.-H., Wu, W., Chan, S. I.,
Chen, C.-J.* “Structural insights into the enzyme catalysis from comparison of three forms of dissimilatory sulfite reductase from Desulfovibrio gigas”. Mol. Microbiol.
2010, 78, 1101–1116.
- Chang, C.-Y., Hsieh, Y.-C., Wang, T.-Y., Chen, Y.-C., Wang Y.-K., Chiang, T.-W., Chen, Y.-J.,
Chen, C.-J.*, Wu, T.-K*. “Crystal structure and mutational analysis of aminoacylhistidine dipeptidase from Vibrio alginolyticus reveal a new architecture of M20 metallopeptidases”. J. Biol. Chem.
2010, 285, 39500–39515.
- Hsieh, Y.-C., Wu, Y.-J., Chiag, T.-Y., Kuo, C.-Y., Shrestha, K. L., Chao, C.-F., Huang, Y.-C., Chuankhayan, P., Wu, W., Li, Y.-K.*,
Chen, C.-J.* “Crystal structures of Bacillus cereus NCTU2 chitinase complexes with chitooligomers reveal novel substrate binding for catalysis: a chitinase without chitin-binding and insertion domains”. J. Biol. Chem. 285,
2010, 31603–31615.
- Chuankhayan, P., Hsieh, C.-Y., Huang, Y.-C., Hsieh, Y.-Y., Guan, H.-H., Hsieh, Y.-C., Tien, Y.-C., Chen, C.-D., Chiang, C.-M.*,
Chen, C.-J.* “Crystal structures of Aspergillus japonicus fructosyltransferase complex with donor/acceptor substrates reveal complete subsites in the active site for catalysis”. J. Biol. Chem.
2010, 285, 23249–23262.
- Guan, H.-H. Guan, Goh, K.-S., Davamani, F., Wu, P.-L., Huang, Y.-W., Jeyakanthan, J., Wu, W.*,
Chen, C.-J.* “Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins”. J. Struct. Biol. 2010, 169, 294–303.
- Chiang, Y.-L., Hsieh, Y.-C., Fang, J.-Y., Liu, E.-H., Huang, Y.-C., Chuankhayan, P., Jeyaraman, J., Liu, M.-Y., Chan, S. I.,
Chen, C.-J.* “Crystal structure of adenylylsulfate reductase from Desulfovibrio gigas suggests a potential self-regulation mechanism involving the C-terminus of the β-subunit”. J. Bacteriol.
2009, 191, 7597–7608.
- Yang, M.-C., Guan, H.-H., Liu, M.-Y., Lin, Y.-H., Yang, J.-M., Chen, W.-L.,
Chen, C.-J.*, Mao, S.J.T.* “Rational design for crystallization of -lactoglobulin and vitamin D3 complex: revealing a secondary binding site”. Cryst. Growth and Des.
2008, 8, 4268–4276.
- Yang, M.-C., Guan, H.-H., Liu, M.-Y., Lin, Y.-H., Yang, J.-M., Chen, W.-L.,
Chen, C.-J.*, Mao, S.J.T.* “Crystal structure of a secondary vitamin D3 binding site of milk -lactoglobulin”. Proteins,
2008, 71, 1197–1210.
- Elmi, F., Lee, H.-T., Huang, J.-Y., Hsieh, Y.-C., Wang, Y.-L., Chen, Y.-J., Shaw, S.-Y.*,
Chen C.-J.* “Stereoselective esterase from Pseudomonas putidareveals an / hydrolase fold for D--acetylthioisobutyric acid synthesis”. J. Bacteriol.
2005, 187, 8470–8476.
- Huang, J.-Y, Chang, T, Chang, C.-Y., Chen, C.-J.* “Crystal structure of a nucleoside diphosphate kinase required for coleoptile elongation in rice (Oryza sativa L.)”. J. Strut. Biol.
2005, 150, 309–318.
- Lee, S.-C., Guan, H.-H., Wang, C.-H., Huang, W.-N., Chen, C.-J.*, and Wu, W.* “Structural basis of venom citrate-dependent heparan sulfate-mediated cell surface retention of cobra cardiotoxin A3”. J. Biol. Chem. 2005, 280, 9567–9577.
|