NSRRC Activity Report 2023

156 NSRRC ACTIVITY REPORT 2023 ( 翁孟慈 ), You-Sheng Lin, and Kuen-Song Lin*( 林錕松 ), “ Dual pH-/ Thermoresponsive Shell-cross-linked Magnetic Mesoporous Nanospheres for Doxorubicin Delivery and In Vitro/In Vivo Cancer Treatment ”, ACS Appl. Nano Mater. 6 , 8416 (2023). ◎ Hwan-Ching Tai*( 戴桓青 ), Chih-Hui Chang, Wenjie Cai, Jer-Horng Lin, Shing-Jong Huang, Qian-Yan Lin, Eric Chung-Yueh Yuan, Shu-Li Li, Ying- Chung Jimmy Lin, Jerry Chun Chung Chan*( 陳振中 ), and Cheng-Si Tsao* ( 曹正熙 ), “ Wood Cellulose Microfibrils Have a 24-chain Core-shell Nanostructure in Seed Plants ”, Nat. Plants 9 , 1154 (2023). • Chia-Hao Tsai, Yan-Cheng Lin*( 林彥丞 ), Wei-Ni Wu, Shih-Hung Tung, Wen-Chang Chen and Cheng-Liang Liu*( 劉振良 ), “ Optimizing the Doping Efficiency and Thermoelectric Properties of Isoindigo-based Conjugated Polymers Using Side Chain Engineering ”, J. Mater. Chem. C 11 , 6874 (2023). • Chia-Hao Tsai, Shih-Hung Tung, Jhih-Min Lin, and Cheng-Liang Liu* ( 劉振良 ), “ A PEDOT: PSS Nanocomposite Film Doped with Black Phosphorus Modified with Silver Nanoparticles for Wearable Photothermoelectric Generators ”, J. Mater. Chem. A 11 , 24890 (2023). • Chuan-Hsin Wang, Manohar Reddy Busireddy, Sheng-Ci Huang, Hebing Nie, Yu-Shuo Liu, Bing-Yong Lai, Ling-Huan Meng, Wei-Tsung Chuang, Markus C. Scharber, Jiun-Tai Chen, and Chain-Shu Hsu*( 許千樹 ), “ Phenoxy Group- containing Asymmetric Non-fullerene Acceptors Achieved Higher V OC Over 1.0 V through Alkoxy Side-chain Engineering for Organic Solar Cells ”, ACS Appl. Mater. Interfaces 15 , 58683 (2023). • David Tzu-Wei Wang, Tiffany Y.-C. Tang, Chun-Ting Kuo, Yun-Ting Yu, Eric H.-L. Chen, Ming-Tao Lee, Ruei-Fong Tsai, Hung-Ying Chen, Yun-Wei Chiang*( 江昀緯 ), and Rita P.-Y. Chen*( 陳佩燁 ), “ Cholesterol Twists the Transmembrane Di-Gly Region of Amyloid-precursor Protein ”, PNAS Nexus 2 , 1 (2023). • Ping-Jui Yu, Yan-Cheng Lin*( 林彥丞 ), Chia-Yu Lin, Wen-Chang Chen*( 陳 文章 ), “ Enhanced Mobility Preservation of Polythiophenes in Stretched States Utilizing Thienyl-ester Conjugated Side Chain ”, Polymer 264 , 125575 (2023). TLS 13B1 SW60 − Protein Crystallography • Jui-Jen Chang, Bang-Jau You, Ni Tien, Yu-Chuan Wang, Chia-Shin Yang, Mei- Hui Hou, Yeh Chen*( 陳曄 ), “ Specific Recognition of Cyclic Oligonucleotides by Cap4 for Phage Infection ”, Int. J. Biol. Macromol. 237 , 123656 (2023). • Yu-Chuan Chiu, Min-Chi Yeh, Chun-Hsiung Wang, Yu-An Chen, Hsiang Chang, Han-You Lin, Meng-Chiao Ho, and Shih-Ming Lin*( 林士鳴 ), “ Structural Basis for Calcium-stimulating Pore Formation of Vibrio α-hemolysin ”, Nat. Commun. 14 , 5946 (2023). • Chiao-Hui Hsieh, Chen-Tsung Huang, Yi-Sheng Cheng, Chun-Hua Hsu, Wen- Ming Hsu, Yun-Hsien Chung, Yen-Lin Liu, Tsai-Shan Yang, Chia-Yu Chien, Yu-Hsuan Lee, Hsuan-Cheng Huang*( 黃宣誠 ), Hsueh-Fen Juan* ( 阮雪芬 ), “ Homoharringtonine as a PHGDH Inhibitor: Unraveling Metabolic Dependencies and Developing a Potent Therapeutic Strategy for High-risk Neuroblastoma ”, Biomed. Pharmacother. 166 , 115429 (2023). • Kuang-Lung Hsueh*( 薛光隆 ), Liang-Kun Yu, Yin-Cheng Hsieh, Ya-Yun Hsiao*( 蕭雅云 ), Chun-Jung Chen, “ FeoC from Klebsiella Pneumoniae Uses Its Iron Sulfur Cluster to Regulate the GTPase Activity of the Ferrous Iron Channel ”, BBA-Proteins Proteomics 1871 , 140855 (2023). • Kuan-Wei Huang, Chia-Yun Wu, Shu-Ing Toh, Tung-Chang Liu, Chun-I Tu, Yin-Hsin Lin, An-Ju Cheng, Ya-Ting Kao, Jhih-Wei Chu*( 朱智瑋 ), and Yu-Yuan Hsiao*( 蕭育源 ), “ Molecular Insight into the Specific Enzymatic Properties of TREX1 Revealing the Diverse Functions in Processing RNA and DNA / RNA Hybrids ”, Nucleic Acids Res. 51 , 11927 (2023). • Meng-Cheng Lai, Hao-Yu Cheng, Sin-Hong Lew, Yu-An Chen, Chien-Hung Yu, Han-You Lin, Shih-Ming Lin*( 林士鳴 ), “ Crystal Structures of Dimeric and Heptameric mtHsp60 Reveal the Mechanism of Chaperonin Inactivation ”, Life Sci. Alliance 6 , e202201753 (2023). • Aitao Li, Qian Wang, Xitong Song, Xiaodong Zhang, Jian-Wen Huang, Chun-Chi Chen, Rey-Ting Guo*( 郭瑞庭 ), Binju Wang*( 王斌舉 ), Manfred T. Reetz*, “ Engineering of a P450-based Kemp Eliminase with a New Mechanism ”, Chin. J. Catal. 47 , 191 (2023). • Jiaxin Li, Patrick T. Kang, Ruisheng Jiang, Jodie Y. Lee, Jitesh A. Soares, Joseph A. Krzycki*, and Michael K. Chan*( 陳文博 ), “ Insights into Pyrrolysine Function from Structures of a Trimethylamine Methyltransferase and Its Corrinoid Protein Complex ”, Commun. Biol. 6 , 54 (2023). • Salila Pengthaisong, Beatriz Piniello, Gideon J. Davies, Carme Rovira*, and James R. Ketudat Cairns*, “ Reaction Mechanism of Glycoside Hydrolase Family 116 Utilizes Perpendicular Protonation ”, ACS Catalysis 13 , 5850 (2023). • Sarita Puri, Cheng-Yu Liu, I-Chen Hu, Chih-Hsuan Lai, Shang-Te Danny Hsu*( 徐尚德 ), Ping-Chiang Lyu*( 呂平江 ), “ Elucidation of the Folding Pathway of a Circular Permutant of Topologically Knotted YbeA by Tryptophan Substitutions ”, Biochem. Biophy. Res. Co. 672 , 81 (2023). • Shu-Ing Toh, Chieh-Ling Lo, and Chin-Yuan Chang*( 張晉源 ), “ Crystal Structure of CmnB Involved in the Biosynthesis of the Nonproteinogenic Amino Acid L -2,3-diaminopropionic Acid ”, Acta Crystallogr. F 79 , 193 (2023). ◎ Wei-Jiun Tsai, Yi-Hsin Lai, Yong-An Shi, Michal Hammel, Anthony P. Duff, Andrew E. Whitten, Karyn L. Wilde, Chun-Ming Wu, Robert Knott, U-Ser Jeng, Chia-Yu Kang, Chih-Yu Hsu, Jian-Li Wu, Pei-Jane Tsai, Chuan Chiang-Ni, Jiunn-Jong Wu, Yee-Shin Lin, Ching-Chuan Liu, Toshiya Senda, and Shuying Wang*( 王淑鶯 ), “ Structural Basis Underlying the Synergism of NADase and SLO During Group A Streptococcus Infection ”, Commun. Biol. 6 , 124 (2023). • Yi-Shiang Wang, Chun-Hsiang Huang, Gunn-Guang Liou, Hsueh-Wen Hsueh, Chi-Ting Liang, Hsi-Ching Tseng, Shing-Jong Huang, Chi-Chao Chao, Sung- Tsang Hsieh, Shiou-Ru Tzeng*( 曾秀如 ), “ A Molecular Basis for Tetramer Destabilization and Aggregation of Transthyretin Ala97Ser ”, Protein Sci. 32 , e4610 (2023). ◎ Yung-Lin Wang, Chin-Yuan Chang, Ning-Shian Hsu, I-Wen Lo, Kuan-Hung Lin, Chun-Liang Chen, Chi-Fon Chang, Zhe-Chong Wang, Yasushi Ogasawara, Tohru Dairi, Chitose Maruyama, Yoshimitsu Hamano*, and Tsung-Lin Li*( 李 宗璘 ), “ N-formimidoylation/-iminoacetylation Requires a Specialized Enzyme Employing FAD-dependent and Ligand-protein NOS Bridge Dual Chemistry ”, Nat. Commun. 14 , 2528 (2023). TLS 13C1 SW60 − Protein Crystallography • Kuan-Wei Huang, Chia-Yun Wu, Shu-Ing Toh, Tung-Chang Liu, Chun-I Tu, Yin-Hsin Lin, An-Ju Cheng, Ya-Ting Kao, Jhih-Wei Chu*( 朱智瑋 ), and Yu-Yuan Hsiao*( 蕭育源 ), “ Molecular Insight into the Specific Enzymatic Properties of TREX1 Revealing the Diverse Functions in Processing RNA and DNA / RNA Hybrids ”, Nucleic Acids Res. 51 , 11927 (2023). • Wilaiwan Kaenying, Takayoshi Tagami, Eukote Suwan, Chariwat Pitsanuwong, Sinchai Chomngam, Masayuki Okuyama, Palangpon Kongsaeree, Atsuo Kimura, Prachumporn T. Kongsaeree*, “ Structural and Mutational Analysis of Glycoside Hydrolase Family 1 Br2 β-glucosidase Derived from Bovine Rumen Metagenome ”, Heliyon 9 , e21923 (2023). • Cheng-Tsung Pan, Chien-Chu Lin, I-Jin Lin, Kun-Yi Chien, Yeong-Shin Lin* ( 林勇欣 ), Hsiao-Han Chang*( 張筱涵 ), Wen-Guey Wu*( 吳文桂 ), “ The Evolution and Structure of Snake Venom Phosphodiesterase (svPDE) Highlight Its Importance in Venom Actions ”, eLife, e83966 (2023). • Yi-Shiang Wang, Chun-Hsiang Huang, Gunn-Guang Liou, Hsueh-Wen Hsueh, Chi-Ting Liang, Hsi-Ching Tseng, Shing-Jong Huang, Chi-Chao Chao, Sung- Tsang Hsieh, Shiou-Ru Tzeng*( 曾秀如 ), “ A Molecular Basis for Tetramer Destabilization and Aggregation of Transthyretin Ala97Ser ”, Protein Sci. 32 , e4610 (2023). TLS 14A1 BM − IR Microscopy ◎ Partha Pratim Biswas, Jagat Rathod, Ching-Yu Chiang, Biqing Liang*( 梁碧清 ), Chun-Chieh Wang, Yao-Chang Lee, Yu-Chun Chuang, Prakash C. Loni, Wei-Hsin Chen, Shan-Li Wang, “ First Principal Observation Documenting the Three-dimensional Uptake of Cadmium and Spatial Distribution of Cadmium Hydroxyapatite Mineral in Bone Char ”, Chemosphere 337 , 139357 (2023). • Po-Liang Chen, Tian-Yun Chang, Pei-Sin Chen, Alvin Hsien-Yi Chan, Adzilah Shahna Rosyadi, Yen-Ju Lin, Pei-Yu Huang, Jia-Xin Li, Wei-Qing Li, Chia-Jui Hsu, Neil Na, Yao-Chang Lee, Ching-Hwa Ho, and Chang-Hua Liu*( 劉昌樺 ), “ Van der Waals Heterostructure Mid-infrared Emitters with Electrically Controllable Polarization States and Spectral Characteristics ”, ACS Nano 17 , 10181 (2023). • Yi-Ting Chen, Pei-Yu Huang, Chee-Yin Chai, Sebastian Yu, Yu-Lin Hsieh, Hao- Chao Chang, Chin-Wei Kuo, Yao-Chang Lee*( 李耀昌 ), and Hsin-Su Yu* ( 余幸司 ), “ Early Detection of the Initial Stages of LED Light-triggered Non- alcoholic Fatty Liver Disease by Wax Physisorption Kinetics-fourier Transform Infrared Imaging ”, Analyst 148 , 643 (2023). • Chen-Tzu Chiu, Jyun-Kai Cao, Pei-Wen Wang, Ya-Na Wu, Yao-Chang Lee, Yeau-Ren Jeng*( 鄭友仁 ), Dar-Bin Shieh*( 謝達斌 ), and Robert R. Reisz*, “ Mammalian Tooth Enamel Functional Sophistication Demonstrated by Combined Nanotribology and Synchrotron Radiation FTIR Analyses ”, iScience 26 , 105679 (2023). ◎ Yen-Lin Cho, Yu-Min Tzou, Chun-Chieh Wang, Yao-Chang Lee, Liang-Ching Hsu, Shao-Lun Liu, Afifah Assakinah, Yu-Hsien Chen, Nhu Anh Thi Than, Yu-Ting Liu*( 劉雨庭 ), Jorg Rinklebe, “ Removal and Concurrent Reduction of Cr(VI) by Thermoacidophilic Cyanidiales: a Novel Extreme Biomaterial Enlightened for Acidic and Neutral Conditions ”, J. Hazard. Mater. 445 , 130334 (2023). • En-Jung Hsieh, Siao-Wei Liao, Ching-Yuan Chang, Chu-Han Tseng, Shan-Li Wang, and Louis Grillet*, “ L-DOPA Induces Iron Accumulation in Roots of Ipomoea Aquatica and Arabidopsis Thaliana in a pH-dependent Manner ”, Bot. Stud. 64 , 24 (2023). • Kuan-Chieh Li, Zong-Hua Wu, Chun-Hung Ke, Yao-Chang Lee, Jyh-Fu Lee, Jin-Ming Chen, Shu-Chih Haw, Fu-Te Tsai*( 蔡富淂 ), Wen-Feng Liaw*