0428同步年報-2021-全

152 ACTIVITY REPORT 2021 Senescence”, Angew. Chem. Int. Edit. 60 , 10756 (2021). • J.-Y. Hong, S.-C. Lin, B.-J. Kuo, and Y.-C. Lo*( 羅玉枝 ), “Structural and Biochemical Basis for Higher-order Assembly between A20-binding Inhibitor of NF-κB 1(ABIN1) and M1-linked Ubiquitins”, J. Mol. Biol. 433 , 167116 (2021). • J.-Y. Hsieh, H.-P. Yang, S. K. Tewary, H.-C. Cheng, Y.-L. Liu, S.-C. Tai, W.-L. Chen, C.-H. Hsu, T.-J. Huang, C.-J. Chou, Y.-N. Huang, C.-T. Peng, M.-C. Ho*( 何孟樵 ), G.-Y. Liu*( 劉俊吉 ), and H.-C. Hung*( 洪慧芝 ), “Single Nucleotide Variants Lead to Dysregulation of the Human Mitochondrial NAD(P) + -dependent Malic Enzyme”, iScience 24 , 102034 (2021). • S.-H. Hsu, S. Zhang, S.-C. Huang, T.-K. Wu, Z. Xu*( 徐正仁 ), and C.-Y. Chang*( 張晉源 ), “Characterization of Enzymes Catalyzing the Formation of the Nonproteinogenic Amino Acid L‑Dap in Capreomycin Biosynthesis”, Biochemistry 60 , 77 (2021). • K.-F. Huang, J.-S. Huang, M.-L. Wu, W.-L. Hsieh, K.-C. Hsu, H.-L. Hsu, T.-P. Ko, and A. H.-J. Wang*( 王惠鈞 ), “A Unique Carboxylic-acid HydrogenBond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes”, J. Mol. Biol. 433 , 166960 (2021). • K.-W. Huang, J.-W. Chen, T.-Y. Hua, Y.-Y. Chu, T.-Y. Chiu, J.-Y. Liu, C.-I. Tu, K.-C. Hsu, Y.-T. Kao, J.-W. Chu*( 朱智瑋 ), and Y.-Y. Hsiao*( 蕭育源 ), “Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites”, JACS Au 1 , 2315 (2021). • E.-S. Lin, Y.-H. Huang, and C.-Y. Huang*( 黃晟洋 ), “Characterization of the Chimeric PriB-SSBc Protein”, Int. J. Mol. Sci. 22 , 10854 (2021). • E.-S. Lin and C.-Y. Huang*( 黃晟洋 ), “Crystal Structure of the Single- stranded DNA-binding Protein SsbB in Complex with the Anticancer Drug 5-fluorouracil: Extension of the 5-fluorouracil Interactome to Include the Oligonucleotide/Oligosaccharide-binding Fold Protein”, Biochem. Biophy. Res. Co. 534 , 41 (2021). • H.-Y. Lin, C.-Y. Chen, T.-C. Lin, L.-F. Yeh, W.-C. Hsieh, S. Gao, P. Burnouf, B.-M. Chen, T.-J. Hsieh, P. Dashnyam, Y.-H. Kuo, Z. Tu, S. R. Roffler*, and C.-H. Lin*( 林俊宏 ), “Entropy-driven Binding of Gut Bacterial β-glucuronidase Inhibitors Ameliorates Irinotecan-induced Toxicity”, Commun. Biol. 4 , 280 (2021). • M.-H. Lin, C.-C. Cho, Y.-C. Chiu, C.-Y. Chien, Y.-P. Huang, C.-F. Chang, and C.-H. Hsu*( 徐駿森 ), “Elucidating the Tunability of Binding Behavior for the MERS-CoV Macro Domain with NAD Metabolites”, Commun. Biol. 4 , 123 (2021). ◎ T.-C. Liu, C.-T. Lin, K.-C. Chang, K.-W. Guo, S. Wang, J.-W. Chu, and Y.-Y. Hsiao*( 蕭育源 ), “APE1 Distinguishes DNA Substrates in Exonucleolytic Cleavage by Induced Space-filling”, Nat. Commun. 12 , 601 (2021). • C. Peng, Y.-H. Li, C.-W. Yu, Z.-H. Cheng, J.-R. Liu, J.-L. Hsu, L.-W. Hsin, C.-T. Huang, H.-F. Juan, J.-W. Chern, and Y.-S. Cheng*( 鄭貽生 ), “Inhibitor Development of MTH1 via High-throughput Screening with Fragment Based Library and MTH1 Substrate Binding Cavity”, Bioorganic Chem. 110 , 104813 (2021). • S.-R. Tzeng*( 曾秀如 ), Y.-C. Tseng, C.-C. Lin, C.-Y. Hsu, S.-J. Huang, Y.-T. Kuo, and C.-I. Chang*( 張崇毅 ), “Molecular Insights into Substrate Recognition and Discrimination by the N-terminal Domain of Lon AAA+ Protease”, eLife 10 , e64056 (2021). TLS 14A1 BM − IR Microscopy ◎ P. P. Biswas, B. Liang*( 梁碧清 ), G. Turner-Walker 2, J. Rathod, Y.-C. Lee, C.-C. Wang, and C.-K. Chang, “Systematic Changes of Bone Hydroxyapatite along a Charring Temperature Gradient: An Integrative Study with Dissolution Behavior”, Sci. Total Environ. 766 , 142601 (2021). ◎ S. I. Chan*( 陳長謙 ), P. Chuankhayan, P. K. R. Nareddy, I.-K. Tsai, Y.-F. Tsai, K. H.-C. Chen, S. S.-F. Yu*( 俞聖法 ), and C.-J. Chen*( 陳俊榮 ), “Mechanism of Pyrroloquinoline Quinone-dependent Hydride Transfer Chemistry from Spectroscopic and High-resolution X‑ray Structural Studies of the Methanol Dehydrogenase from Methylococcus capsulatus (Bath)”, J. Am. Chem. Soc. 143 , 3359 (2021). ◎ S.-W. Chang, R.-G. Chen, T.-H. Liu, Y.-C. Lee, C.-S. Chen, T.-S. Chiu, and C.-Y. Ko*( 柯佳吟 ), “Dietary Shifts and Risks of Artifact Ingestion for Argentine Shortfin Squid Illex Argentinus in the Southwest Atlantic”, Front. Mar. Sci. 8 , 675560 (2021). ◎ Y. Cheng, H. Sun, E. Yang, J. Lv, B. Wen, F. Sun, L. Luo*( 羅磊 ), and Z. Liu, “Distribution and Bioaccessibility of Polycyclic Aromatic Hydrocarbons in Industrially Contaminated Site Soils as Affected by Thermal Treatment”, J. Hazard. Mater. 411 , 125129 (2021). • A.-C. Chu, R. S. Sahu, T.-H. Chou, and Y.-H. Shih*( 施養信 ), “Magnetic Fe 3 O 4 @TiO 2 Nanocomposites to Degrade Bisphenol A, One Emerging Contaminant, Under Visible and Long Wavelength UV Light Irradiation”, J. Environ. Chem. Eng. 9 , 105539 (2021). • R.-H.o Guo, C.-M. Chou, C.-C. Wang, M.-J. Deng*( 鄧名傑 ), J.-M. Lin, C.-Y. Chen, Y.-C. Lee, Y.-W. Chiang, and W.-T. Chuang*( 莊偉綜 ), “Biomimetic Strategies for 4.0 V All-solid-state Flexible Supercapacitor: Moving Toward Eco-friendly, Safe, Aesthetic, and High-performance Devices”, Chem. Eng. J. 414 , 128842 (2021). • S. R. Kumar, Y.-H. Hsu, T. T. T. Vi, J.-H. S. Pang, Y.-C. Lee, C.-H. Hsieh* ( 謝佳訓 ), and S. J. Lue*( 呂幸江 ), “Graphene Oxide-induced Protein Conformational Change in Nasopharyngeal Carcinoma Cells: A Joint Research on Cytotoxicity and Photon Therapy”, Materials 14 , 1396 (2021). • R. S. Sahu*, Y.-H. Shih*( 施養信 ), and W.-L. Chen, “New Insights of Metal Free 2D Graphitic Carbon Nitride for Photocatalytic Degradation of Bisphenol A”, J. Hazard. Mater. 402 , 123509 (2021). • R. S. Sahu*, A. Dubey, and Y.-H. Shih*( 施養信 ), “Novel Metal-free In- plane Functionalized Graphitic Carbon Nitride with Graphene Quantum Dots for Effective Photodegradation of 4-bromophenol”, Carbon 182 , 89 (2021). • P. Uthaiwat, J. Daduang*, A. Priprem, C. Settasatian, S. Chio-Srichan, Y.-C. Lee, P. Mahakunakorn, and P. Boonsiri, “Topical Melatonin Niosome Gel for the Treatment of 5-FU-induced Oral Mucositis in Mice”, Curr. Drug Deliv. 18 , 199 (2021). • P. Uthaiwat, A. Priprem, S. Chio-Srichan, C. Settasatian, Y.-C. Lee, P. Mahakunakorn, P. Boonsiri, C. Leelayuwat, P. Tippayawat, P. Puthongking, and J. Daduang*, “Oral Administration of Melatonin or Succinyl Melatonin Niosome Gel Benefits 5-FU-induced Small Intestinal Mucositis Treatment in Mice”, AAPS PharmSciTech 22 , 200 (2021). • Y.-S. Yan, Y.-H. Chen*( 陳燕華 ), C.-C. Wang, Y. Hwu, Y.-C. Lee, H.-S. Sheu, and C.-C. Chiang, “Faults Caused by the Fault: Microstructural and Mineral Characterization of Deformation in Chungliao Tunnel, Taiwan, Caused by Chishan Fault”, Eng. Geol. 292 , 106245 (2021). TLS 15A1 Biopharmaceuticals Protein Crystallography • S. Baiya, S. Pengthaisong, S. Kitjaruwankul, and J. R. K. Cairns*, “Structural Analysis of Rice Os4BGlu18 Monolignol β-glucosidase”, PLoS One 16 , e0241325 (2021). ◎ S. I. Chan*( 陳長謙 ), P. Chuankhayan, P. K. R. Nareddy, I.-K. Tsai, Y.-F. Tsai, K. H.-C. Chen, S. S.-F. Yu*( 俞聖法 ), and C.-J. Chen*( 陳俊榮 ), “Mechanism of Pyrroloquinoline Quinone-dependent Hydride Transfer Chemistry from Spectroscopic and High-resolution X‑ray Structural Studies of the Methanol Dehydrogenase from Methylococcus capsulatus (Bath)”, J. Am. Chem. Soc. 143 , 3359 (2021). ◎ C.-C. Chen, X. Han, X. Li, P. Jiang, D. Niu, L. Ma, W. Liu, S. Li, Y. Qu, H. Hu, J. Min, Y. Yang, L. Zhang, W. Zeng, J.-W. Huang*( 黃建文 ), L. Dai*( 戴隆海 ), and R.-T. Guo*( 郭瑞庭 ), “General Features to Enhance Enzymatic Activity of Poly(Ethylene Terephthalate) Hydrolysis”, Nat. Catal. 4 , 425 (2021). • C.-C. Chen, S. R. Malwal, X. Han, W. Liu, L. Ma, C. Zhai, L. Dai, J.-W. Huang, A. Shillo, J. Desai, X. Ma, Y. Zhang, R.-T. Guo*( 郭瑞庭 ), and E. Oldfield*, “Terpene Cyclases and Prenyltransferases: Structures and Mechanisms of Action”, ACS Catalysis 11 , 290 (2021). • Y.-C. Chiu, T.-S. Hsu, C.-Y. Huang, and C.-H. Hsu*( 徐駿森 ), “Molecular