0428同步年報-2021-全

138 ACTIVITY REPORT 2021 List of Publications Publications (including conference proceedings) listed here are based on the results obtained from facilities associated with the NSRRC. Note: 1. Asterisks (*) indicate corresponding authors. Their Chinese names are shown in parentheses if applicable. 2. Publications are sorted by endstation and listed in alphabetic order according to the last name of the first author. 3. Publications using more than one beamline are listed in corresponding beamline sections. 4. Publications marked ◎ are selected to report in the section of Research Highlights. TPS 05A Protein Microcrystallography • T. Arimori, N. Miyazaki, E. Mihara, M. Takizawa, Y. Taniguchi, C. Cabañas, K. Sekiguchi, and J. Takagi*, “Structural Mechanism of Laminin Recognition by Integrin”, Nat. Commun. 12 , 4012 (2021). • J. Chan, F. Qinqin, L. Jianwei, C. Ying, S. Machida, C. Wei, Y. A. Yuan, and C. Jobichen*, “Structural and Mechanistic Insight Into Stem-loop RNA Processing by Yeast Pichia Stipitis Dicer”, Protein Sci. 30 , 1210 (2021). ◎ S. I. Chan*( 陳長謙 ), P. Chuankhayan, P. K. R. Nareddy, I.-K. Tsai, Y.-F. Tsai, K. H.-C. Chen, S. S.-F. Yu*( 俞聖法 ), and C.-J. Chen*( 陳俊榮 ), “Mechanism of Pyrroloquinoline Quinone-dependent Hydride Transfer Chemistry from Spectroscopic and High-resolution X‑ray Structural Studies of the Methanol Dehydrogenase from Methylococcus capsulatus (Bath)”, J. Am. Chem. Soc. 143 , 3359 (2021). ◎ C.-C. Chen, X. Han, X. Li, P. Jiang, D. Niu, L. Ma, W. Liu, S. Li, Y. Qu, H. Hu, J. Min, Y. Yang, L. Zhang, W. Zeng, J.-W. Huang*( 黃建文 ), L. Dai*( 戴隆海 ), and R.-T. Guo*( 郭瑞庭 ), “General Features to Enhance Enzymatic Activity of Poly(Ethylene Terephthalate) Hydrolysis”, Nat. Catal. 4 , 425 (2021). • C.-C. Chen, S. R. Malwal, X. Han, W. Liu, L. Ma, C. Zhai, L. Dai, J.-W. Huang, A. Shillo, J. Desai, X. Ma, Y. Zhang, R.-T. Guo*( 郭瑞庭 ), and E. Oldfield*, “Terpene Cyclases and Prenyltransferases: Structures and Mechanisms of Action”, ACS Catalysis 11 , 290 (2021). • S.-C. Chen, L.-C. Ye, T.-M. Yen, R.-X. Zhu, C.-Y. Li, S.-C. Chang, S.-H. Liaw*( 廖淑惠 ), and C.-H. Hsu*( 徐駿森 ), “Crystal Structures of Aspergillus Oryzae Rib2 Deaminase: the Functional Mechanism Involved in Riboflavin Biosynthesis”, IUCrJ 8 , 549 (2021). • Y.-C. Chiu, T.-S. Hsu, C.-Y. Huang, and C.-H. Hsu*( 徐駿森 ), “Molecular Elucidation of a Urate Oxidase from Deinococcus Radiodurans for Hyperuricemia and Gout Therapy”, Int. J. Mol. Sci. 22 , 5611 (2021). • Y.-C. Chiu, T.-S. Hsu, C.-Y. Huang, and C.-H. Hsu*( 徐駿森 ), “Structural and Biochemical Insights into a Hyperthermostable Urate Oxidase from Thermobispora Bispora for Hyperuricemia and Gout Therapy”, Int. J. Biol. Macromol. 188 , 914 (2021). ◎ Y.-C. Chiu, M.-C. Tseng, and C.-H. Hsu*( 徐駿森 ), “Expanding the Substrate Specificity of Macro Domains toward 3”, ACS Catalysis 11 , 11075 (2021). • L. Dai, L. Qin, Y. Hu, J.-W. Huang, Z. Hu, J. Min, Y. Sun*( 孫媛霞 ), and R.-T. Guo*( 郭瑞庭 ), “Structural Dissection of Unnatural Ginsenoside- biosynthetic UDP-glycosyltransferase Bs-YjiC from Bacillus Sbtilis for Substrate Promiscuity”, Biochem. Biophy. Res. Co. 534 , 73 (2021). • H.-H. Guan, Y.-H. Huang, E.-S. Lin, C.-J. Chen*( 陳俊榮 ), and C.-Y. Huang*( 黃晟洋 ), “Plumbagin, a Natural Product with Potent Anticancer Activities, Binds to and Inhibits Dihydroorotase, a Key Enzyme in Pyrimidine Biosynthesis”, Int. J. Mol. Sci. 22 , 6861 (2021). • H.-H. Guan, Y.-H. Huang, E.-S. Lin, C.-J. Chen*( 陳俊榮 ), and C.- Y. Huang*( 黃晟洋 ), “Structural Basis for the Interaction Modes of Dihydroorotase with the Anticancer Drugs 5-fluorouracil and 5-aminouracil”, Biochem. Biophy. Res. Co. 551 , 33 (2021). • H.-H. Guan, Y.-H. Huang, E.-S. Lin, C.-J. Chen*( 陳俊榮 ), and C.-Y. Huang*( 黃晟洋 ), “Complexed Crystal Structure of Saccharomyces Cerevisiae Dihydroorotase with Inhibitor 5-fluoroorotate Reveals a New Binding Mode”, Bioinorg. Chem. Appl. 2021 , 2572844 (2021). • K.-F. Huang, J.-S. Huang, M.-L. Wu, W.-L. Hsieh, K.-C. Hsu, H.-L. Hsu, T.-P. Ko, and A. H.-J. Wang*( 王惠鈞 ), “A Unique Carboxylic-acid HydrogenBond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes”, J. Mol. Biol. 433 , 166960 (2021). • K.-W. Huang, J.-W. Chen, T.-Y. Hua, Y.-Y. Chu, T.-Y. Chiu, J.-Y. Liu, C.-I. Tu, K.-C. Hsu, Y.-T. Kao, J.-W. Chu*( 朱智瑋 ), and Y.-Y. Hsiao*( 蕭育源 ), “Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites”, JACS Au 1 , 2315 (2021). ◎ C.-R. Jhan, R. Satange, S.-C. Wang, J.-Y. Zeng, Y.-C. Horng, P. Jin, S. Neidle, and M.-H. Hou*( 侯明宏 ), “Targeting the ALS/FTD-associated A-DNA Kink with Anthracene-based Metal Complex Causes DNA Backbone Straightening and Groove Contraction”, Nucleic Acids Res. 49 , 9526 (2021). • Y. Katsuyama*, K. Sone, A. Harada, S. Kawai, N. Urano, N. Adachi, T. Moriya, M. Kawasaki, K. Shin-ya, T. Senda*, Y. Ohnishi, “Structural and Functional Analyses of the Tridomain-nonribosomal Peptide Synthetase FmoA3 for 4-methyloxazoline Ring Formation”, Angew. Chem. Int. Edit. 60 , 14554 (2021). • Y. Kitaoku, T. Fukamizo*, S. Kumsaoad, P. Ubonbal, R. C. Robinson*, and W. Suginta*, “A Structural Model for (GlcNAc) 2 Translocation via a Periplasmic Chitooligosaccharide-binding Protein From Marine Vibrio Bacteria”, J. Biol. Chem. 297 , 101071 (2021). ◎ T.-P. Ko, Y.-C. Wang, C.-L. Tsai, C.-S. Yang, M.-H. Hou, and Y. Chen* ( 陳曄 ), “Crystal Structure and Functional Implication of a Bacterial Cyclic AMP-AMP-GMP Synthetase”, Nucleic Acids Res. 49 , 4725 (2021). • W.-C. Kuo, C.-C. Lee, Y.-W. Chang, W. Pang, H.-S. Chen, S.-C. Hou, S.-Y. Lo, A.-S. Yang, and A. H.-J. Wang* ( 王惠鈞 ), “Structure- based Development of Human Interleukin-1β-specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP”, J. Mol. Biol. 433 , 166766 (2021). • L.-C. Lee, Y.-H. Peng, H.-H. Chang, T. Hsu, C.-T. Lu, C.-H. Huang, C.-C. Hsueh, F.-C. Kung, C.-C. Kuo*( 郭靜娟 ), W.-T. Jiaang*( 蔣維棠 ), and S.-Y. Wu*( 伍素瑩 ), “Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2)”, J. Med. Chem. 64 , 11288 (2021). ◎ T.-C. Liu, C.-T. Lin, K.-C. Chang, K.-W. Guo, S. Wang, J.-W. Chu, and Y.-Y. Hsiao*( 蕭育源 ), “APE1 Distinguishes DNA Substrates in Exonucleolytic Cleavage by Induced Space-filling”, Nat. Commun. 12 , 601 (2021). • D. M. Mwangangi, E. Manser, and R. C. Robinson*, “The Structure of the Actin Filament Uncapping Complex Mediated by Twinfilin”, Sci. Adv. 7 , eabd5271 (2021). • S. Sadotra, Y.-C. Lou, H.-C. Tang, Y.-C. Chiu, C.-H. Hsu*( 徐駿森 ), and