中心簡介 / 同仁通訊錄

蛋白質繞射小組


姓名： 黃駿翔( Chun-Hsiang Huang )
分機： 7348
電子郵件： huang.conann@nsrrc.org.tw
學歷：
  • 國立陽明大學生化暨分子生物研究博士(2008)
經歷：
  • 同步輻射研究中心助研究員(2015-)
  • 中國科學院天津工業生物技術研究所副研究員(2010-2014)
  • 中央研究院基因體研究中心博士後(2009-2010)
負責實驗站：
  • BL13B1，BL13C1, BL15A1 and TPS 05A
研究領域：
  • X光蛋白質結晶學
代表作：
  • Chan HC, Ko TP, Huang CH and Guo RT. Minireviw: A comeback of Hg-derivatives in protein crystallography with Cys-modification. ChemBioEng Rev. (2015) 2: 133-140
  • Huang CH, Zhen Z, Cheng YS, Chan HC, Ko TP, Chen CC, Wang I, Ho MR, Hsu ST, Zeng YF, Huang YN, Liu JR and Guo RT. Structure and catalytic mechanism of a glycoside hydrolase family-127 β-L-arabinofuranosidase (HypBA1). Journal of Bioprocessing & Biotechniques (2014) in press
  • Chan HC, Feng X, Ko TP, Huang CH, Hu Y, Zheng Y, Bogue S, Nakano C, Hoshino T, Zhang L, Lv P, Liu W, Crick DC, Liang PH, Wang AH, Oldfield E, and Guo RT. Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. J Am Chem Soc. (2014) 136:2892-2896
  • Cheng YS, Huang CH*, Chen CC, Huang TY, Ko TP, Huang JW, Wu TH, Liu JR, and Guo RT. Structural and mutagenesis analyses of a 1,3-1,4-β-glucanase from Paecilomyces thermophile. Biochim Biophys Acta. (2014) 1844:366-373. (*co-first author)
  • Huang CH, Sun Y, Ko TP, Chen CC, Zheng Y, Chan HC, Pang X, Wiegel J, Shao W, and Guo RT. The substrate/product-binding modes of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485. Biochem. J. (2012) 448:401-407
  • Liu W, Sun Y, Ko TP, Weigel J, Shao W, Guo RT, and Huang CH. Crystallization and preliminary X-ray diffraction analysis of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485. Acta Crystallogr Sect F Struct Biol Cryst Commun. (2012) F68: 914-16
  • Ren F, Ko TP, Feng X, Huang CH, Chan HC, Hu Y, Wang K, Ma Y, Liang PH, Wang AH, Oldfield E, and Guo RT. Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes. Angew.Chem Int. (2012) 51(17):4157-60
  • Wu TH, Huang CH*, Ko TP, Lai HL, Ma Y, Chen CC, Cheng YS, Liu JR, Guo RT. Diverse substrate recognition mechanism revealed by Thermotoga maritime Cel5A structures in complex with cellotetraose, cellobiose and mannotriose. Biochim Biophys Acta. (2011) 1814(12):1832-40 (*co-first author)
  • Huang CH, Winkler A, Chen CL, Lai WL, Tsia YC, Macheroux P, Liaw SH. Functional roles of the 6-S-cysteinyl, 8α-N1-histidyl FAD in glucooligosaccharide oxidase from Acremonium strictum. J Biol Chem. (2008) 283(45):30990-6
  • Huang CH, Lai WL, Lee MH, Chen CJ, Vasella A, Tsai YC, Liaw SH. Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8α-N1-histidyl FAD. J Biol Chem. (2005) 280(46):38831-8