margination effect, targeted therapy, lung cancer, Gd2O3, X-ray powder diffraction, X-ray absorption near-edge spectroscopy
The Collaborative Research of NSRRC User Chen-Sheng Yeh and Researcher Hwo-Shuenn Hsu Highlighted as a Cover of ACS Applied Materials & Interfaces
2022/03/28
The NSRRC user, Prof. Chen-Sheng Yeh in Chemistry at National Cheng Kung University, worked in collaboration with Dr. Wen-Pin Su in College of Medicine at National Cheng Kung University, Prof. Ting-Yuan Tu in Biomedical Engineering at National Cheng Kung University, Prof. Chia-Hao Su in Translational Research in Biomedicine of Kaohsiung Chang Gung Memorial Hospital, and NSRRC Researcher Dr. Hwo-Shuenn Hsu, for the research on the application of nanoparticle-based drugs in different shapes in magnetic resonance (MR) imaging-guided X-ray irradiation, regarded as a targeted therapy for lung cancer. Their latest research results were published in the international journal ACS Applied Materials & Interfaces, and were highlighted as the supplementary cover of the March 23rd issue.
In the research, the team reported the preparation of Gd2O3 nanoparticles in three different shapes (sphere, scroll, and oblate) which were used to evaluate the impact of the marginative delivery on the therapeutic efficacy. The oblate one turned out to outperform the other two to suppress tumors and exhibited the best antitumor activity. Gd2O3 nanoparticles not only revealed to be promising MR imaging contrast agents, but also showed significant potential in inhibition of lung tumor growth with the combination of X-ray irradiation at a low dose of 1 Gy and MR imaging. Synchrotron radiation was used for the first time to systematically investigate the efficacy of X-ray treatments for tumors in terms of the chemical structures of Gd2O3 in different shapes, oxidation state, charge transfer, and orbital hybridization on the molecular scale. In particular, the team used the techniques of X-ray powder diffraction at TLS 01C2 and X-ray absorption near-edge spectroscopy at TLS 01C1 for data collection, measurement and analysis of the crucial Gd2O3 nanomaterials.
