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Chen-Sheng Yeh, Chia-Hao Su, Hwo-Shuenn Sheu, long-lasting luminescence, Advanced Materials, NSRRC, synchrotron radiation X‐ray‐excited radioluminescence, concave nanocubes
Prof. Chen-Sheng Yeh, Prof. Chia-Hao Su, and Dr. Hwo-Shuenn Sheu Contribute to A Medical Breakthrough in Tumor Detection
The research team composed of Chair Prof. Chen-Sheng Yeh (Center of Applied Nanomedicine, National Cheng Kung Univ.), Prof. Chia-Hao Su (Inst. for Translational Research in Biomedicine, Chang Gung Memorial Hospital), and Dr. Hwo-Shuenn Sheu (NSRRC) has made a medical breakthrough – imaging deep-seated tissues using low dose of X-ray-excited long-lasting luminescent concave nanocubes. This innovation was not only published in a prestigious journal, Advanced Materials, but also given 2019 FutureTech Demo and Breakthrough Award in Taiwan. The clinical trials are expected to start within 5 years. Industrial Technology Research Inst. has also shown an interest in commercializing this technology.

After two years of devotion, Prof. Yeh finally discovered the optimal choice for imaging deeper tissue. Through the collaboration with Dr. Sheu, X-ray excited radioluminescence (XRL) spectra of concave nanocubes were obtained from synchrotron radiation X‐ray‐excited radioluminescence (SRXRL), which was performed at both TPS 09A and TLS 01C2. Meanwhile, Prof. Su observed long-lasting luminescence imaging acquired from health mice and tumor-bearing mice. This new optical bioimaging technique considerably eliminates tissue autofluorescence interference, as well as overcomes the tissue penetration limitation. Tumors can be located and tracked more precisely now that it has been shown that the afterglow lasts for up to 3 hours. Low dose of X-ray excitation of long-lasting luminescent concave nanocubes could be an effective non-penetrating method for diagnosing deep-seated orthotropic tumors in the near future.